头针加药物治疗早期脑梗死患者外周血丙二醇含量变化与神经功能康复的研究

Changes of Serum MDA Content and Neurological Rehabilitation in Cerebral Infarction Patients Treated with Scalp-acupuncture plus Medication

目的 :探讨头针应用于脑梗死 (CI)早期的作用。方法 :60例早期CI患者 ,随机分为A、B两组 ,B组采用CI早期常规药物治法 ,A组在B组治疗基础上加用头针 ,每日 1次 ,10次为 1疗程。治疗结束后进行外周血丙二醇 (MDA)检测、神经功能评分 ,并对MDA含量与神经功能评分进行相关分析。结果 :两组治疗后均可显著改善MDA及神经功能评分的情况 (P <0 .0 1) ,A组疗效优于B组 ,治疗前后MDA含量与神经功能评分均呈显著正相关 (P <0 .0 5)。结论 :头针应用于CI早期治疗时 ,对MDA及神经功能改善有肯定的作用。

Objective: To observe the effect of scalp-acupuncture plus medication on serum malondialdehyde (MDA) content and neurological functions in cerebral infarction (CI) patients at the early stage. Methods:A total of 60 CI patients were randomly divided into routine medication group (n=30) and scalp-acupuncture plus routine medication (acupuncture) group (n=30). In addition, 30 healthy subjects were used as normal control group. Routine medication refers to supporting treatment (medicines for regulating blood pressure and blood sugar, maintaining balance of water, electrolytes and acid-base scale), improving cerebral circulation (low molecular dextran, red sage root injection, fleabane injection), dilating cerebral blood vessels, suppressing platelet agglutination and activating cerebral tissue metabolism. Dingnie Qianxiexian (MS 6) was used as the main point for CI patients who chiefly manifested dyscinesia; Dingnie Houxiexian (MS 7) selected for patients who chiefly manifested sensory disturbance; or both of them were used for motor disturbance combined with sensory disturbance, supplemented with Dingzhongxian (MS 5) and Dingpangxian I (MS 8). Acupuncture treatment was given once daily, with 10 times being a therapeutic course. Results: Before treatment, serum MDA contents of medication and acupuncture groups were significantly higher than that of normal control group (P<0.01). Following one course of treatment, comparison between post- and pre-treatment of each group showed that MDA levels (5.68±0.56 pg/mL vs 6.11±0.26 pg/mL; 5.08±0.27 pg/mL vs 6.05±0.24 pg/mL) and the scales of neurological deficit (11.70±3.63 vs 19.36±6.25; 9.43±3.76 vs 19.30±6.66) in both medication and acupuncture groups all decreased significantly (P<0.01). There was a positive correlation between the scales of neurological deficit and MDA contents before and after treatment (r=0.488, P<0.05).Conclusion:Scalp-acupuncture can effectively lower serum MDA and improve CI patients’ neurological functions.