摘要
目的:总结原发性食管小细胞癌的病理及临床生物学特征,重点探讨外科治疗经验及影响疗效的因素。方法:对全部36例(活检标本14例,手术标本22例)进行病理形态学观察及免疫组化标记,10例电镜观察。对接受手术治疗的22例的疗效进行回顾性分析。结果:大体形态多为溃疡隆起型,镜下形态分为燕麦细胞型和非燕麦细胞型。接受手术治疗的22例按1997年新的国际食管癌TNM分期标准,Ⅰ期2例、Ⅱ期10例(Ⅱa期4例、Ⅱb期6例)、Ⅲ期10例。手术后1、2、3年和5年生存率分别为63.6%,38.8%,13.3%,9.0%,最长生存者已达11年,中位生存期16个月。结论:原发性食管小细胞癌恶性程度高、预后差,肿瘤的TNM分期仍是影响其疗效的重要因素。如何早期发现和对早期患者实施以手术为主的综合治疗是提高疗效的关键。
Objective: To summarize the clinicopathologic characteristics and the experience in treatment of primary small cell carcinoma (SCC) of esophagus, and to investigate the factors influencing patients' survival. Methods: 36 cases SCC of the esophagus were observed macroscopically and microscopically. 22 cases undergone surgical treatment were analysed retrospectively. Results: under microscope, two types of SCC, i.e. oat-type(16/36) and non oat-type (20/36) were divided. According to The New TNM Classification in Esophageal Carcinoma(1997), within the 22 cases undergone surgical treatment, 2 cases were in stage Ⅰ, 10 cases in stage Ⅱ and the other 10 cases in stage Ⅲ. The 1, 2, 3 and 5-year survival rate of them were 63.6%, 38.8%, 13.3%, 9.0% respectively, average 16 months. Conclusions: SCC of esophagus is a kind of highly malignant neuroendocrine tumor with poor prognosis. The TNM staging and modality of operation are the important influencing factors in long-term survivals. The survival term may be prolonged by early detection of the SCC, early surgical intervention and adjuvant multi-modality treatments.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第19期1106-1107,1110,共3页
Chinese Journal of Clinical Oncology
关键词
食管肿瘤
病理
外科治疗
预后
Esophageal neoplasm Pathology Surgical treatment Prognosis