雌激素和孕激素受体在非小细胞肺癌中的表达

Expression of Estrogen and Progesterone Receptors in Non-Small Cell Lung Carcinoma

目的:检测非小细胞肺癌组织中雌激素受体、孕激素受体的表达与临床病理、肿瘤分化程度、患者年龄及性别的关系。方法:用免疫组织化学SP法检测66例非小细胞肺癌组织标本中ER、PR的表达。结果:ER和PR的总阳性率分别为59.3％和64.1％,鳞癌和腺癌的ER阳性率分别为56.2％和62.5％,PR阳性率分别为56.2％和71.8％。雌孕激素受体阳性率与肿瘤分化程度具有相关性,而与肿瘤组织学分型、患者性别、年龄等无关。结论:肺癌组织中存在性激素受体,可能对肺癌的治疗有一定指导价值。

Object: To investigate the expression of estrogen receptors (ER) and progesterone receptors (PR) in non-small cell lung cancer and relation with type of pathyology, tumor differentiation and age of the patients. Methods: 66 resected speciments of lung cancer were examined. ER and PR were detected using immunohistochemical staining. Results: The overall positive rate for ER were 59.3%, and 62.5% for PR. In squamas carcinoma, 56.% were positive for both ER and PR. In adeno-carcinoma 62.5%were positive for ER and 71.8% for PR. There was a significant correlation between ER and PR positive percentage and degrees of histological differentiation in lung cancer, while ER and PR percentage appears to have no relationship with histological type, age and sex of patients. Conclusion: it is clear that ER and PR are present in non-small cell lung cancer. These result may provide a basis for adjuvant therapy in lung cancer patients.