羟基喜树碱和顺铂联合化疗治疗晚期非小细胞肺癌的疗效观察

Effect of combination Hydroxycamptothcin with Cisplatin for treatment of advanced NSCLC

目的 探讨羟基喜树碱 (HCPT)联合顺铂 (DDP)化疗方案 (HP)与长春瑞滨 (NVB)联合 DDP化疗方案 (NP)治疗非小细胞肺癌 (NSCL C)的疗效及毒副作用。方法 实验组给予 HCPT6 mg/ m2 静滴第 1～ 5天 ,DDP30 mg/ m2 静滴第 1～ 3天 ,2 1天为一周期。对照组给予 NVB2 5 mg/ m2 静滴第 1、8天 ;DDP30 mg/ m2 静滴第 1～3天 ,2 1天为一周期。结果 实验组有效率为 35 % (7/ 2 0 ) ,对照组有效率为 4 0 % (8/ 2 0 ) ,两组有效率差异无统计学意义 (X2 =0 .11,P>0 .0 5 )。实验组主要不良反应为恶心、呕吐及腹泻和轻度的骨髓抑制 , 、 度白细胞减少明显比对照组少 (P<0 .0 5 ) ,实验组与对照组其他不良反应发生率无明显差异 (P>0 .0 5 )。结论 HCPT联合 DDP是治疗晚期 NSCL C有效的方案 ,毒副反应轻 ,患者耐受性好 ,值得进一步在临床中推广。

Objective To observe the effect and toxicity of HP regimen:Hydroxycamptothecin (HCPT) combined with Cisplatin(DDP) and NP reginmen:vinobelbine(NVB) combined with DDP in treatment of advanced non-small cell lung cancer(NSCLC).Methods A total of 40 cases NSCLC were enrolled in this study.The tested group(20cases)received HP regimen:HCPT 6mg/m 2d 1-5,DDP30mg/m 2d 1-3,q3W,and the control group(20cases)received NP:NVB 25mg/m 2d 1,8,DDP30mg/m 2d 1～3,q3W.Results In tested group,the effective rate was 35%(7/20),whereas that of control group was 40%(8/20).The difference of effective rates between two groups was not statistically significant(P>0.05).The main adverse reactions of tested group were nausea,vomiting,diarrhea and mild neutropenia. There was a significant difference in Ⅲ+Ⅳ of neutropenia of tested group and control group(P<0.05),and the difference of other adverse reactions between the two groups was not statisically significant(P>0.05).Conclusion The combined regimen of HCPT with DDP for treating advanced NSCLC has a high response rate and tolerable side effects.it can be used for treating advanced NSCLC.