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早期选择性抑制神经元型一氧化氮合酶对鼠脑外伤的治疗作用 被引量：1

Experimental study on the selective inhibitor of nNOS in treatment of traumatic brain injury in rats.
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摘要 目的　探讨选择性抑制神经元型一氧化氮合酶 (nNOS)对脑外伤的治疗作用。方法　 6 0只SD大鼠建立在自由落体脑外伤模型基础上 ,随机平均分成 6个小组 :3组大鼠分别在伤后 3h、6h、9h给予nNOS的选择性抑制剂 7 硝基吲唑 (7 NI) ,另 3组于伤后对应时间给予生理盐水作为对照 ,大鼠在伤后 2 4h取脑检测其NOS活性、Ca2 + 含量、含水量。结果　 7 NI于伤后第 3h、6h给药组 ,其脑组织中NOS活性、Ca2 + 含量、含水量均低于盐水对照组 ,7 NI于伤后第 9h给药组上述指标与盐水对照组无显著差异。 Objective To study the effects of the selective inhibitor of nNOS, 7-Nitroindazole (7-NI), in the treatment of traumatic brain injury in rats. Methods Sixty SD rats underwent traumatic brain injury according to Feeneny method. Animals were randomly divided into 6 grounds equally: 7-NI treated at 3, 6, 9 h after injury and saline treated at 3, 6, 9 h after injury. The NOS activity, contents of Ca 2+ and water of brain tissue were measured 24 h after injury. Results The NOS activity, content of Ca 2+ and water of brain tissue in 7-NI treated at 3, 6 h after injury were significantly reduced as compared with controls. 7-NI treated at 9 h after injury couldn't reduce above index. Conclusion Early using the selective inhibitor of nNOS may represent a potential therapeutic strategy for traumatic brain injury.
作者 赵时雨 袁先厚 文志华
机构地区 武汉大学中南医院脑外科
出处 《华中医学杂志》 2004年第5期278-279,共2页 Central China Medical Journal
关键词 治疗作用 脑外伤 神经元型一氧化氮合酶 对照组 药组 NOS活性 SD大鼠 CA^2+ 盐水 Brain injuries Nitric-Oxide synthase Rats 7-Nitroindazole
分类号 R651.15 [医药卫生—外科学] R289 [医药卫生—方剂学]
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参考文献4

  • 1程毓华,王卫东,孙莉莎,程祖珏,徐江平.NOS抑制剂对成年大鼠弥漫性脑损伤后海马齿状回神经发生的影响[J].第一军医大学学报,2003,23(10):1074-1077. 被引量：14
  • 2Xia Y, Dawson Vl, Oawson TM et al. Nitric oxide synthase generates superoxide and nitric oxide in arginine - depleted cells leading to peroxynitrite mediated cellular injury.Proc Natl Acal Sci USA, 1996,93(9) :6770
  • 3Feeney DM, Boyeson MG, Linn RT et al. Responses to cortical injury: Methodlogy and local effects of contusion in the rat. Brain Res, 1981,211(1):67
  • 4Wada K, Chatzipanteli k, Busto R et al. Role of nitric oxide in traumatic brain injury in the rat. J Neurosurg, 1998,89(11) :807

二级参考文献14

  • 1Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al. Neurogenesis in the adult human hippocampus [ J ]. Nat Med, 1998, 4(11): 1313-7.
  • 2Gage FH. Neurogenesis in the adult brain[J]. J Neurosci, 2002, 22(3): 612-3.
  • 3Dash PK, Mach SA, Moore AN. Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury[J]. J Neurosci Res,2001, 63(4): 313-9.
  • 4Marmarou A, Foda MA, van den Brink W, et al. A new model of diffuse brain injury in rats. Part 1: Pathophysiology and biomechanics[J]. J Neurosurg, 1994, 80(2): 291-300.
  • 5Higuchi Y, Hattori H, Kume T, et al. Increase in nitric oxide in the hypoxic-ischemic neonatal rat brain and suppression by 7-nitroindazole and aminoguanidine[J]. Eur J Pharmacol, 1998, 342(1):47-9.
  • 6Nakagawa E, Aimi Y, Yasuhara O, et al.Enhancement of progenitor cell division in the dentate gyrus triggered by initial seizures in rat models of epilepsy[J]. Epilepsia, 2000, 41(1): 10-8.
  • 7Zhang R, Zhang L,Zhang Z, et al.A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats[J].Ann Neurol, 2001, 50(5): 602-11.
  • 8Orihara Y, IKematsu K, Tsuda R, et al. Induction of nitric oxide syathase by traumatic brain injury[J]. Forensic Sci Int,2001, 123(2-3): 142-9.
  • 9Dun NJ, Dun SL, Wong RK, et al. Colocalization of nitric oxide synthase and somatostatin immunoreactivity in rat detltate hilar neurons[J]. Proc Natl Acad Sci USA, 1994, 91(8): 2955-9.
  • 10包新民,舒斯云,曾建新.大鼠全脑缺血后纹状体边缘区内一氧化氮合酶、神经肽Y表达的变化[J].第一军医大学学报,2001,21(9):644-647. 被引量：8

共引文献13

同被引文献15

  • 1梁有明,刘运生,李创华,王光伟,屈洪涛.局灶低温治疗大鼠脑外伤对脑组织氧自由基影响的研究[J].中国耳鼻咽喉颅底外科杂志,2004,10(5):257-259. 被引量：12
  • 2毛青,江基尧.颅脑外伤后继发性脑损害发病机制的研究进展[J].中华神经医学杂志,2005,4(2):200-202. 被引量：25
  • 3RosenfeId JV,Maas Al,Bragge P,et al.Early management of severe traumatic brain injury[J].Lancet,2012,380(9847):1088-1098.
  • 4Wada K,Chatzipanteli K,Busto R,et al.Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat[J],J Neuro- trauma,1999,16(3):203-212.
  • 5Berger RP,Beers SR,Richichi R,et al.Serum biomarker concentrations and outcome after pediatric traumatic brain injury[J].J Neurotrauma,2007,24(12);1793-1801.
  • 6Fukushima M,Lee SM,Moro N,et al Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury[J].J Neurotrauma,2009,26(7):1095-1110.
  • 7Wada K,ChatzipanteIi K,Busto R,et al.Role of nitric oxide in traumatic brain injury in the rat[J].J Neurosurg,1998,89(5):807-818.
  • 8Khan M,Dhammu TS,Matsuda F,et al.Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI[J].Brain Res,2016,1630:159-170.
  • 9Ondruschka B,Pohlers D,Sommer G,et al.S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases[J].J Neurotrauma,2013,30(22):1862-1871.
  • 10Bohmer AE,Oses JP,Schmidt AP,et al Neuron-specific enolase,S100B,and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury[J],Neurosurgery,2011,68(6):1624-1630.

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华中医学杂志
2004年 第5期

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