血清固定梅毒患者细胞免疫研究

Study on cellular immunity of serofast of patients with syphilis

目的 检测血清固定梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞 ,探讨梅毒患者血清固定与细胞免疫的相关性。方法 应用流式细胞仪检测 2 2例血清固定梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞 ,并与 30例健康人群的检测结果相对照。结果 血清固定梅毒患者外周血CD3及CD4淋巴细胞均低于对照组 ,差异有显著性 (P <0 0 5 ) ;而CD8及NK淋巴细胞高于对照组 ,差异有显著性 (P <0 0 5 )。结论 血清固定梅毒患者存在明显的细胞免疫不平衡和免疫抑制 ;

Objective To detect the T-lymphocyte subsets and NK cell of peripheral blood of serofast of patients with syphilis and to explore the relationship between the serofast and cellular immunity in these patients. Methods T-lymphocyte subsets and NK cell of peripheral blood were measured with flow cytometry(FCM) in 22 serofast of patients with syphilis. Results The results revealed that CD3 and CD4 lymphocytes were significantly lower than those in the controls( P <0 05), consequently, CD8 and NK lymphocytes in patients was significantly higher than those in the controls( P <0 05). Conclusion These findings suggest that there are imbalance and suppression of cellular immunity in the peripheral blood of serofast of patients with syphilis and these imbalance and suppression may be the main reason of serofast.