p73、PTEN在大肠癌中的表达

The Expression of p73, PTEN in colorectal carcinoma

目的 检测p73、PTEN基因在大肠癌组织中的表达 ,并研究其临床病理意义。方法 采用逆转录聚合酶链式反应 (RT PCR)法检测p73、PTEN在 4 0例大肠癌中的表达。结果 ①DuckesA、B期大肠癌组织与对照组正常大肠黏膜组织p73、PTEN的表达均有非常显著性差异 (P <0 0 1) ;DuckesC、D期与A、B期p73、PTEN的表达均有非常显著性差异 (P <0 0 5 )。②p73在高、中分化腺癌组与低分化腺癌组阳性率表达无显著性差异 (P >0 0 5 ) ;而PTEN在高、中分化腺癌和低分化腺癌阳性率表达差异具有显著性 (P <0 0 5 )。③p73、PTEN在淋巴结转移组与无淋巴结转移组检出阳性率的差异具有显著性 (P <0 0 5 )。结论 p73、PTEN的表达与大肠癌临床病理特征和生物学行为存在密切关系 ;p73。

Objective To explore the expression of tumor-related genes(p73 and PTEN) and their clinic pathological significances in colorectal cancer tissues. Methods The expression of p73, PTEN from 40 patients with colorectal carcinoma were investigated by RT-PCR. Results ①There existed significant differences between normal control and Dukes A,B( P <0 01); as well as the Dukes C.D with Dukes A.B for the expression of p73, PTEN.( P <0 05) ②In the high or middle differentiation grade of the cancer detected, the expression of p73 bear inconspicuous discrepancies to the low grade'( P >0 05), but in the same condition PTEN got the opposite results. ③There existed significant differences between the expression rates of p73 and PTEN in the patients with lymph metastasis and those without lymph metastasis( P <0 05). Conclusion The expressions of p73 and PTEN has close relationship with the pathology of colorectal carcinoma and their own biology behaviors. Both p73 and PTEN play important roles in the distinct hyperplasia of colorectal carcinoma.