医用放射性核素的载体——磁性壳聚糖微球的制备

The Carriers of Radionuclides in Therapy--Preparation Study of Magnetic Chitosan Microspheres

采用乳化交联法制备了可附载放射性核素的磁靶向药物载体--磁性壳聚糖微球,磁性微球中的纳米磁性Fe34粒子由FeSO4和FeCl3通过碱溶液的共沉淀法制备而得,借助SEM、IR及激光粒度仪等对微球的粒径、粒径分布和形貌进行了表征。结果表明:在壳聚糖溶液质量分数为1.5％,Fe3O4与壳聚糖的质量比为1:2,悬浮介质的搅拌速度为1200r/min等条件下制得的磁性壳聚糖微球的粒径在(40±20)μm,且呈规则的球形,可满足放射性核素载体的基本要求。

In this paper, magnetic chitosan microspheres which can load radionuclides were prepared by the suspension cross-linking technique (size distribution 40μm±20μm). The magnetic material (i. e. Fe3O4) loaded in the preparation of the magnetic chitosan microspheres was prepared by coprecipitation from solution of FeSO4 and FeCl3 in basic medium. The size, size distribution and morphology of the chitosan microspheres were studied by means of SEM, IR and MASTERSIZE. The best experiment conditions were demonstrated as following: the concentration of chitosan solution at 1.5%, Fe3Q4/chitosan ratio at 1 : 2, stirring rate of the suspension medium at 1200r/min-1. The size of chitosan microspheres prepared under these conditions were about 40μm±20μm, and the morphology was all sphericity. The above results of magnetic chitosan micropheres were fitted for the basic request for the carriers of radionuclides.