重组人类促红细胞生成素预防极低出生体重儿贫血的研究

Clinical comparison study of recombinant human erythropoietin in preventing anemia of very-low-birth-weight infants

目的 评价重组人类促红细胞生成素 (rhu EPO)在相同剂量下不同应用频度对预防极低出生体重儿(VLBWI)贫血的效果。方法 将东南大学附属徐州医院儿科 2 0 0 1年 9月至 2 0 0 3年 9月收治的 2 2例VLBWI随机分成两组 ,均在出生第 8天开始予rhu EPO ,每周 75 0IU/kg ,共 6周。Ⅰ组 (12例 )每周 3次给药 ;Ⅱ组 (10例 )每周 1次给药。另设未予rhu EPO的 12例VLBWI作为对照组 (Ⅲ组 )。动态观察血红蛋白、红细胞计数、红细胞压积比等。结果 (1) 3组患儿在出生第 2 8天血红蛋白值的差异均有统计学意义 (P <0 0 1) ,出生第 6 4天的差异有统计学意义 (P <0 0 1) ,但Ⅰ、Ⅱ组间 P =0 0 5 2。 (2 ) 3组患儿在出生第 2 8天红细胞计数的差异均有统计学意义(P <0 0 1) ,出生第 6 4天的差异有统计学意义 (P <0 0 1) ,但Ⅰ、Ⅱ组间P =0 0 74。 (3) 3组患儿在出生第 2 8天红细胞压积比的差异有统计学意义 (P <0 0 1) ,但Ⅰ、Ⅱ组间P =0 14 0 ,出生第 6 4天的差异有统计学意义 (P <0 0 1) ,但Ⅰ、Ⅱ组间P =0 195。结论 在rhu EPO相同的每周总量下 ,每周 3次给药比每周

Objective To compare the effects of preventing anemia of very-low-birth-weight infants(VLBWI)between one and three times a week dosages of recombinant human erythropoietin (rhu-EPO) using the same weekly dose. Methods 22 VLBWI who were given rhu-EPO 750 IU/kg/week for 6 weeks from the eighth day of life were randomly divided into two groups:Ⅰgroup (n=12,three times a week dosage) and Ⅱgroup (n=10,once a week dosage).12 VLBWI without receiving rhu-EPO were considered as the control group(Ⅲ group).Hemoglobin,red blood cells count and hematocrit values were recorded in the three groups,respectively.Results (1)There was statistically significant difference among the groups in the values of hemoglobin on the twenty-eighth day of life (P<0 01).There was statistically significant difference among the groups on the sixty-fourth day of life (P<0 01),but there was no statistically significant difference betweenⅠand Ⅱ group (P value=0 052).(2) There was statistically significant difference among the groups in the red blood cells count on the twenty-eighth day of life (P<0 01).There was statistically significant difference among the groups on the sixty-fourth day of life (P<0 01),but there was no statistically significant difference betweenⅠand Ⅱ group (P value=0 074).(3) There was statistically significant difference among the groups in the values of hematocrit on the twenty-eighth day of life (P<0 01),but there was no statistically significant difference betweenⅠand Ⅱ group (P value=0 140).There was statistically significant difference among the groups on the sixty-fourth day of life (P<0 01),but there was no statistically significant difference betweenⅠand Ⅱ group (P value=0 195).Conclusion More frequent dosing of the same weekly amount of rhu-EPO produced a significant increase in the values of hemoglobin and red blood cells count in VLBWI.