摘要
本文采用单向免疫扩散法对131名铅作业工人血清免疫球蛋白(IgG、IgA、IGM)的含量进行了测定。同时采用原子吸收分光光度计测定了血液中微量元素Zn、Cu、Fe、Pb及尿Pb的含量。结果表明:铅接触组中血清IgG、IgA均低于对照组;IgM、IgG与铅接触者血铅含量呈高度负相关;尿铅与血铅呈明。明显的剂量一反应关系;当平均血铅值在0.02mg/dl以上时,血液中Zn、Cu、Fe微量元素出现了不同程度的降低。因此,我们认为金属毒物铅对机体的体液免疫及微量元素Zn、Cu、Fe可能有不同程度的抑制作用。检测免疫球蛋白和有关微量元素含量的变化,对了解铅的毒性有一定的参考价值。至于能否将血清中免疫球蛋白和微量元素的变化当作诊断铅毒性的敏感指标之一,尚需进一步观察和探讨。
The authors determined the serum immunoglobuin (IgG、IgA、IgM) with immunodiffusion method and the content of the microelements(Zn、Cu、Fe、Pb) in blood and the content of lead in the urine of 131 people whose work was relted to lead. The results show that the content of serum IgG、IgA on the lead-contact group is lower than that of the control group. The IgM and IgG have a highly negative relation with the blood lead content of lead contacters. The content of urine and blood lead has a clear dose-response relation,so it is believed that lead has a restrictive effect on the immunity and microelements of the body Detection of immunoglobulin and relative microelements can be a reference in understanding the toxicity of lead.
