心力衰竭患者血脑钠素与心功能相关研究

A study of the correlation between the serum brain natriuretic peptide level and the cardiac function in patients with heart failure

目的 研究心力衰竭 (心衰 )患者血浆脑纳素 (BNP)水平与心衰严重程度、左室功能等因素的关系。方法 采用免疫放射分析法测定 12 2例心衰患者治疗前后和 2 0例对照组血浆 BNP浓度 ;用心脏彩色多普勒超声诊断仪测定左室射血分数 (L VEF)、左心室舒张末期内径 (L VEDD)。结果 心衰患者 BNP浓度显著高于对照组 (P<0 .0 1) ;BNP水平随着心功能纽约分级 (NYHA)程度的加重而显著增高 ,其与 L VEF呈负相关 (r=- 0 .34,P<0 .0 0 1)。治疗后随心功能好转 BNP浓度下降 ,L VEDD明显改善 (P<0 .0 5 )。结论 心衰患者血 BNP水平随着心力衰竭严重程度的增加而升高 ,并能较好反映左室功能状态。

Objective To investigate the correlation between the serum brain natriuretic peptide (BNP) level and the severity of heart failure (HF) or the left ventricular function (LVF) in patients with HF. Methods 122 patients with HF before and after treatment and 20 control subjects were investigated by measuring the serum BNP level, the left ventricular ejection fraction (LVEF) and the left ventricular end-diastolic diameter (LVEDD). Results The serum BNP level in patients with HF were markedly higher than those in control subjects (P<0.01), but the exent of the BNP level increase was closely correlated with the severity of HF in NYHA functional class, reversely, the BNP level correlated negatively to the LVEF (r=-0.34,P<0.001). After treatment the LVEDD in patients with HF was obviously improved (P<0.05), however, the serum BNP level was notably decreased with the cardiac function better. Conclusions These results indicate that the exent of the BNP level increase is closely correlative with the severity of HF, furthermore, the BNP level also better reflects the LVF.