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HIV与T细胞凋亡 被引量:4

HIV and T cell apoptosis
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摘要 T细胞介导的细胞免疫为机体消除或抑制艾滋病病毒(HIV)感染所必需,其中又以CD4+T细胞和细胞毒性T淋巴细胞(CTL)细胞为主,同时两者又是HIV感染的主要受害者。观察发现,CD4+T细胞的凋亡数量远远超过了被感染细胞,这与HIV蛋白、激活介导细胞死亡(AICD)、细胞因子生成紊乱密切相关。本文从以上三方面综述了HIV感染者体内CD4+T细胞衰竭机制,并从Th细胞与CTL相互作用的角度,总结了Th细胞减少对机体细胞免疫的影响。
出处 《国外医学(流行病学.传染病学分册)》 2004年第5期273-275,279,共4页 Epidemiology Lemology Foreign Medical Sciences
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