细胞免疫与持续性丙型肝炎病毒感染
被引量：2
Cellular immune response and persistent hepatitis C virus infection
摘要
急性丙型肝炎患者容易转变为持续性丙型肝炎病毒(HCV)感染,在慢性HCV感染中存在细胞免疫 (尤其是HCV特异性记忆T细胞数量和功能)的异常,本文就有关细胞免疫,特别是记忆T细胞在丙型肝炎慢性化 过程中的意义以及作用机制进行综述。
基金
国家自然科学基金资助(30200232)
参考文献28
-
1Frank C, Mohamed MK, Strickland GT, et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet,2000,355: 887-891.
-
2Chang KM. Immunopathogenesis of hepatitis C virus infection. Clin Liver Dis,2003,7(t) :89-105.
-
3Sugimoto K, Stadanlick J, Ikeda F, et al. Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response. Hepatology, 2003,37 (3): 590-599.
-
4Esser MT, Marchese RD, Kierstead LS, et al. Memory T cells and vaccines. Vaccine, 2003,21 (5-6) :419-430.
-
5Fearon DT, Manders P, Wagner SD. Arrested differentiation, the self-rerewing memory lymphocyte, and vaccination. Science, 2001,293 (5528):248-250.
-
6Masopust D, Vezys V, Marzo AL, et al. Preferential localization of effector menorycells in nonlymphoid tissue. Science, 2001,291 (5512): 2413-2417.
-
7Ley K, Kansas GS. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol,2004,4(5) :325-336.
-
8Day CL, Seth NP, Lucas M, et al. Ex vivo analysis of human memory CD4T cells specific for hepatitis C virus using MHC class Ⅱ tetramers. J Clin Invest,2003,112(6): 831-842.
-
9Nascimbeni M, Mizukoshi E, Bosmann M, et al. Kinetics of CD4+ and CD8 + memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees. J Virol, 2003,77 (8): 4781-4793.
-
10Rosen HR, Miner C, Sasaki AW, et al. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology, 2002,35 (1) : 190-198.
同被引文献13
-
1刘德洪,封林.猪瘟病毒持续感染与免疫失败的关系[J].畜禽业,2004,15(8):58-59. 被引量：1
-
2Esser MT,Marchese RD,Kierstead LS,et al.Memory T cells and vaccines.Vaccine,2003,21(5-6):419～430
-
3Fearon DT,Manders P,Wagner SD,Arrested differentiation,the self-renewing memory lymphocyte,and vaccination.Science,2001,293(5528):248～250
-
4Masopust D,Vezys V,Marzo Al,et al.Preferential localization of effector memory cells in nonlymphoid tissue.Science,2001,291(5512):2413
-
5Esser MT,Marchese RD,Kierstead LS,et al.Memory T cells and vaccines.Vaccine,2003,21(5～6):419～430.
-
6Fearon DT,Manders P,Wagner SD,Arrested differentiation,the self-renewing memory lymphocyte,and vaccination.Science,2001,293 (5528):248～250.
-
7Masopust D,Vezys V,Marzo Al,et al.Preferential localization of effector memory cells in nonlymphoid tissue.Science,2001,291(5512):2413.
-
8刘德洪,封林.猪瘟病毒持续感染与免疫失败的关系[J].兽医导刊,2004,0(6):23-24. 被引量：1
-
9杨希谦,李建远,张永福.乙型肝炎病毒持续性感染防治策略的研究进展[J].中国生物制品学杂志,2000,13(4):254-255. 被引量：5
-
10覃保业,孙淑兰,吴健敏.病毒的持续感染及其产生机理[J].中国兽医杂志,2001,37(4):32-33. 被引量：4
-
1闫彩萍,张秀莲,张伟华,肖虹,范星火,陈玮,侯素敏,刘晨.再生障碍性贫血骨髓组织中白细胞介素-17的表达及其意义[J].中国药物与临床,2011,11(8):910-911. 被引量：3
-
2加、美科学家发现艾滋病病毒在人体内藏身之地——记忆T细胞，有助于研发治愈艾滋病的新方法[J].生物学教学,2010,35(1):78-79. 被引量：1
-
3张彬彬,朱思和,蔡卫民.α干扰素对慢性丙型肝炎患者血清肝纤维化指标的影响[J].中华肝脏病杂志,2003,11(10):622-623. 被引量：3
-
4张林,祝纯礼,张大志.免疫耐受与乙型肝炎病毒的持续感染[J].现代医药卫生,2010,26(3):395-397.
-
5刘冠军,王合群,殷海燕,蔡俊岭.急性丙型肝炎52例临床分析[J].中原医刊,2005,32(15):61-62. 被引量：1
-
6李娟,程成.肝纤维化血清学指标与乙型和丙型肝炎关系的临床流行病学分析[J].地方病通报,2009,24(5):1-3. 被引量：1
-
7申卫红,朱岚,张晴菊.FOXP3在急性丙型肝炎患者中的表达及其临床意义[J].南京医科大学学报（自然科学版）,2010,30(2):242-244. 被引量：2
-
8蒋道荣,姚登福,董志珍,邱历伟,陆建新.急性丙型肝炎患者病毒株部分基因克隆及其序列分析[J].中华肝脏病杂志,2000,8(3):153-155. 被引量：1
-
9侯金林,孙剑.丙型肝炎的抗病毒治疗[J].中华肝脏病杂志,2004,12(2):105-105.
-
10陈祖贵,宋小平,冷强,闵福援,胡宏.急性丙型肝炎患者NK细胞活性和T细胞亚群研究[J].免疫学杂志,1993,9(3):178-180.
