期刊文献+

雌激素水平与绝经后血管性痴呆患者认知功能的关系 被引量:3

Relationship between Estrogen and Cognition of Post menopausal Women with Vascular Dementia
下载PDF
导出
摘要 目的探讨雌激素(E)水平与绝经后血管性痴呆(VD)患者认知功能的关系。方法绝经后VD患者48例,随机分为VD1组和VD2组各24例,分别给予维尼安2mg与安慰剂1片口服,每月2次,治疗4个月;绝经后健康妇女18例为正常组。3组分别于治疗前及治疗后2和4个月时测定血浆雌二醇水平(E2)和低密度脂蛋白胆固醇(LDLC)水平,简易智能量表(MMSE)测定认知功能。结果VD组患者E2水平明显低于正常组(P<0.05)。VD1组经过维尼安治疗4个月后,E2水平逐渐上升(P<0.01),LDLC逐渐下降(P<0.05),MMSE评分逐渐提高(P<0.05);E2水平与LDLC水平呈显著负相关性(P<0.01);与MMSE评分呈正相关性(P<0.05)。结论E替代治疗有利于改善绝经后VD患者的认知功能。 Objective: To study the relationship between estrogen level and cognition of post menopausal women with vascular dementia (VD). Methods: Forty eight VD cases were assigned to two groups randomly: VD1 and VD2 group who were subjected to nilestrial replacement therapy or placebo treatment respectively for 4 months. At the 0, 2nd and 4th month of treatment, serous estradiol (E 2) and low density lipoprotein cholesterol (LDL C) levels were measured, and cognition was measured by mini mental state examination (MMSE) too. Results: E 2 level in the VD group was lower than that in the normal group ( P <0.05). After nilestrial treatment, E 2 level was increased ( P <0.01), and LDL C level decreased ( P <0.05)in the VD1 group. Meanwhile, MMSE was raised ( P <0.05). There was a significant negative correlation between E 2 level and LDL C level ( P <0.01), while a positive correlation between E 2 level and MMSE ( P <0.05). Conclusion: Estrogen replacement therapy is effective to cognition of post menopausal women with VD.
出处 《中国康复》 2004年第5期272-273,共2页 Chinese Journal of Rehabilitation
关键词 雌激素 血管性痴呆 认知功能 低密度脂蛋白 estrogen vascular dementia cognition low density lipoprotein
  • 相关文献

参考文献8

  • 1王晓鹏,李春岩,耿连霞,刘瑞春,董梅,王志红.性激素水平与脑梗塞及相关因素关系的研究[J].脑与神经疾病杂志,2003,11(3):158-160. 被引量:20
  • 2McEwen Bs. Clinical review 108: The molecular and neuroatomical basis for estrogen effects in the central nervous system [J]. J Clin Endocrinol Metab, 1999,84(6): 1790- 1797.
  • 3Krishnankutty S, Garry L, Jennings S. Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women[J]. Hypertension, 1996,28(3) :330-334.
  • 4Wakatsuki A, Sagara Y. Lipoprotein metabolism in postmenopausal and ophorectomized women[J]. Obatet Gyncol, 1995,85: 523- 528.
  • 5Nabulsi AA, Folsom AR,White A,et al. Association of homone-replacement therapy with various cardiovascular risk factors in postmenopausal women[J]. N Engl J Med, 1993,328:1069-1075.
  • 6Sarrel PM, Lufkin EG, Oursler MJ, et al. Estrogen action in arteries, bone and brain[J]. Scientific American, 1994,14(3) :44-53.
  • 7杨春,周度金.雌激素与早老性痴呆病[J].国外医学(临床生物化学与检验学分册),1999,20(3):114-115. 被引量:5
  • 8Paganini Hill A, Henderson VW. Estrogen deficiency and risk of alzheimeris disease in women[J]. Am J Epidimiol, 1994,140(3) :256-261.

二级参考文献15

  • 1方桂远,张琳.男性脑梗塞患者性激素和凝血与纤溶指标的观察[J].中风与神经疾病杂志,1995,12(4):222-223. 被引量:10
  • 2Alkyed NJ, Harukuni I, Kimes AS, et al. Gender-linked hbrain injury in esperimental stroke, Stroke, 1998,29:159~166.
  • 3Simpkins JW, Rajakumar G, Zhand YQ, et al. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg, 1997,87;724~730.
  • 4Toung TJK, Traystman Rajakumar RJ, Hurn PD, et al. Estrogenmediated neuroprotection after experimental stroke in male rats,Stroke, 1998,29:1666~1670.
  • 5Nabulsi AA, Polsom AR, White A, et al, Assoiation of hormonereplacement oimen. N Engl J Med, 1993,328:1069~1075.
  • 6Sarrel PM, Lufkin EG,Oursler M J, et al, Estrogen action in arteries, bone and brain, Scientific American 1994:44~53.
  • 7Jeppesen LL, Jorgensen HS, Nakayama H, et al, Decreased serum testosterone in with acute ischemic, Artrioscler Thromb Vase Biol,1996,16;749.
  • 8White RE, Darkow DJ Lang JL, Estrogen relaxes coronary arteries by opening BK-ca channel through a Cgmp-dependent mechanism,Cite Res, 1995,77:936~942.
  • 9Hurn PD, Littleton-Kearney MT, Kirsch JR, et al, Postischemic ecrebral blood flow recovery in the females ;effect of 17B-estradil, J Cereb Blood Flow Metab, 1995,15(4) :666~672.
  • 10Laheenmaki P, Passi V, Laukkainen T, Cogulation factors in women using oval contraceptives devices after abortion, AM J Obstect, 1981,141~175.

共引文献23

同被引文献55

  • 1姜晓蕊,卢宏,冯建玉,滕军放,宋志宇,王建平.17-β雌二醇对血管性痴呆大鼠BDNF表达的影响[J].实用神经疾病杂志,2005,8(2):39-41. 被引量:15
  • 2周建军,张馨,徐运.雌激素对老年性痴呆的防治作用及其分子机制的新进展[J].国外医学(神经病学.神经外科学分册),2005,32(1):99-102. 被引量:7
  • 3Sherwin BB.Estrogen and cognitive functioning in women[J].Endocr Rev,2003,24:133-51.
  • 4Henderson VW,PaganiniHill A,Miller BL,et al.Estrogen for Alzheimer′s disease in women:randomized,double-blind,placebo-controlled trial[J].Neurology,2000;54:295-301.
  • 5Zandi PP,Carison MC,Plassman BL,et al.Hormone replacement therapy And incidence of Alzheimer disease in older women.The Cache County study[J].J Am Med Assoc,2002;288:2123-9.
  • 6Compton J,Murphy D.HRT and its effect on normal ageing of the brain and dementia[J].Blackwell Science Ltd Br J Clin Pharmacol,2001;52:647-53.
  • 7Shumaker SA,Legault C,Rapp SR,et al.Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women:The Women's Health Initiative Memory Study:a randomized controlled trial[J].J Am Med Assoc,2003;289:2651-62.
  • 8Duka T,Tasker R,McGowan JF.The effects of estrogen hormone replacement on congnition in elderly healthy females[J].Psychopharmacology,2000;149:129-39.
  • 9Monk D,Brodaty H.Use of estrogen for the prevention and treatment of Alzheimer's disease[J].Dement Geriatr Cong Disord,2000;11:1-10.
  • 10Horvath KM, Hartig W, Van der Veen R, et al. 17-β estradiol en hances cortical cholinergic innervation and preserves synaptic density following excitotoxic lesions to the rat nucleus basalis magnocellularis[J]. Neuroscience,2002,110 (3) :489--504.

引证文献3

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部