老年心房颤动患者脑缺血发生与血清脂蛋白(a)水平的关系研究

Relationship between cerebral ischemia and serum level of lipoprotein(a) in old people with chronic atrial fibrillation

目的 :探讨老年慢性心房颤动 (AF)患者脑缺血发生 (包括短暂性脑缺血发作及脑梗死或脑栓塞 )与血清脂蛋白 (a) [LP(a) ]浓度之间的关系。方法 :无脑缺血发生的慢性AF患者 70例 ,3个月以内曾出现脑缺血发作的慢性AF患者 6 2例 ,另选取有器质性心脑血管病但无AF的患者 6 4例作为对照组。采用酶联免疫吸附法(ELISA)测定LP(a)水平。结果 :脑缺血发生组LP(a)浓度显著高于无脑缺血发生组及对照组 (P <0 .0 5 ,P <0 .0 1) ,而无脑缺血发生组与对照组之间差异无统计学意义 (P >0 .0 5 )。结论 :老年慢性AF患者血清LP(a)浓度升高可能是导致脑缺血发作的原因之一。

Objective:To investigate relationship between occurrence of cerebral ischemia(including transient ischemic attack, cerebral infarction and cerebral embolism) and level of lipoprotein(a) [Lp(a)]in old people with chronic atrial fibrillation(AF). Method:The level of LP(a) was detected by enzyme-linked immunosorbent assay(ELISA) in 132 patients with chronic AF and in 64 control cases. The AF patients were divided into a group of 70 patients with cerebral ischemia occurred recently and a group of 62 patients without cerebral ischemia recently, and a group of 64 patients with organic cardiovascular or cerebrovascular diseases but without AF was control group. Result:The concentrations of LP(a) was significantly higher in the cerebral-ischemia group than that of the non -cerebral-ischemia group and control group. However, there was no difference between the non- cerebral-ischemia group and control group. Conclution: Increase of LP(a) in older patients with chronic AF may be one of the important factors for occurence of cerebral ischemia.