血清脂联素水平与冠状动脉病变程度的关系

The relationship between serum level of adiponectin and severity of coronary artery stenosis

目的 :研究血清脂联素与冠状动脉 (冠脉 )病变狭窄程度的相关性以及对血管病变稳定性的预测价值。方法 :入选 10 5例男性患者 ,分为 3组 ,急性冠脉综合征 (ACS)患者 5 1例 ,稳定型心绞痛 (SAP)患者 2 9例 ,非冠心病对照组 2 5例 ,进行血清脂联素测定 ,采用Gensini积分系统评定冠脉血管病变狭窄程度。结果 :ACS组血清脂联素水平的对数值 [(0 .6 4± 0 .18)mg/L]明显低于SAP组和对照组 [(0 .81± 0 .2 1)、(0 .81± 0 .2 8)mg/L],均P <0 .0 1。而SAP组和对照组之间差异无统计学意义 (P >0 .0 5 )。脂联素与冠脉病变程度Gensini积分呈负相关 (r =- 0 .38,P <0 .0 1)。结论 :脂联素与冠脉狭窄程度以及稳定性显著相关 ,有助于临床评价冠心病病变程度及其进展。

Objective: To investigate the relationship between the level of serum adiponectin and the severity,stability of coronary artery stenosis. Method:We studied total of 105 male patients. Serum concentration of adiponectin in 51 patients with acute coronary syndrome(ACS),29 patients with stable angina pectoris(SAP) ,diagnosed by coronary angiograph, were measured . There were 25 normal control subjects.The severity scale of coronary artery stenosis was quantatively assessed according to coronory angiography by Gensini score. Result: The serum levels of adiponectin in ACS patients were significantly descended as compared with that of SAP and controls(P< 0.01),and serum adiponectin concentration were negatively correlated with the severity of coronaru artery stenosis(r=- 0.38,P< 0.01). Conclusion:Adiponectin reflects the severity and stability of coronary artery stenosis which may predicts the occurrence and development of coronary artery disease.