摘要
目的 观察全血灌流免疫吸附治疗重症肌无力的疗效。方法 以电鳗乙酰胆碱受体α亚单位Ta183 2 0 0段多肽为免疫源建立实验性自身免疫性重症肌无力动物模型 ,用以纤维素为载体、色氨酸为配基的吸附剂IM MG对实验兔进行全血灌流吸附治疗 ,比较治疗前后临床症状、抗体滴度、神经电生理功能的变化。结果 IM MG灌流治疗 2h ,能清除 (4 8 5 4± 2 4 7) %的致病抗体 ,肌无力症状显著改善 ;3、 5、10Hz重复神经电刺激实验复合动作电位衰减率明显恢复 (P <0 0 5 ) ,从治疗前的 (2 1 88± 7 2 4 ) %、(2 3 88± 7 4 2 ) %和 (2 5 75± 5 97) %依次恢复到 (16 0 0± 6 78) %、 (16 88± 7 4 2 ) %和 (17 5 0± 7 5 8) %。结论 IM MG全血灌流吸附治疗能有效清除重症肌无力动物体内的致病抗体 ,并相应改善肌无力症状 ,提高神经肌肉电传导功能 。
Objective To investigate the effects of systemic hemoperfusion adsorption in the treatment of myasthenia gravis.Methods Myasthenia gravis (MG)models in rabbits were produced by immunization with Tal83-200 and treated with systemic hemoperfusion.The clinical improvement was evaluated through clinical score,antibody titers,and changes in neuroelectrophysiological function.Results The pathogenic antibodies of Tal83-200 were removed by(48.54±2.47)% at 2 h after treatment.The attenuation percentage of compound muscle action potential at 3,5,10Hz in MG rabbits decreased from(21.88±7.24)%,(23.88±7.42)% and (25.75±5.97)% to (16.00±6.78)%,(16.88±7.42)% and (17.50±7.58)%,respectively.Conclusion Systemic hemoperfusion adsorption could remove pathogenic antibodies in MG effectively,and improve clinical manifestation and neuromuscular function.It may be considerated in the future for treating myasthenic crisis.
出处
《中华急诊医学杂志》
CAS
CSCD
2004年第10期670-672,i001,共4页
Chinese Journal of Emergency Medicine
基金
天津市社会发展计划项目 ( 0 3 3 1114 11)
关键词
治疗
灌流
全血
重症肌无力
致病
抗体
IM
疫源
症状
实验兔
Myasthenia gravis
Systemic hemoperfusion
Antibody
Neuromuscular transmission function