季铵盐催化合成β-硝基对氯苯乙烯

Catalytic Synthesis of β-nitro-p-chloro-phenylethylene with Quaternary Ammonium Salt PTCA

以季铵盐PTCA作相转移催化剂,通过Henry反应,在醋酸铵/冰乙酸存在的条件下,用对氯苯甲醛与硝基甲烷缩合合成β 硝基对氯苯乙烯。研究了不同相转移催化剂的催化活性、催化剂的用量、反应时间、反应温度和反应物物料量比对反应产率的影响。实验结果表明:季铵盐PTCA是一种优良的相转移催化剂;以季铵盐PTCA为相转移催化剂,反应物料量比n对氯苯甲醛∶n硝基甲烷为1.0∶1.8,反应温度为78℃,反应时间为2h,在弱酸性条件下进行反应,产率达74.25%。

β-nitro-p-chloro-phenylethylene was catalytically synthesized by Henry reaction with the quaternary ammonium salt PTCA as phase transfer catalyst (PTC) in this paper. The effects of the phase transfter catalyst the amount of reagent, PTC reagent amount, reaction temperature, reaction time and the mole ratio of reactant compounds on yield were investigated.The results show that the yield of 74.25% can be obtained at 78 ℃ for 2 h under the optimal reaction conditions, in which the mole ratio of 4-chloro-benzaldehyd and nitromethane is 1.0∶1.8.