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功能磁共振成像的脑能量代谢机制 被引量：2

Mechanism of Cerebral Energy Metabolism Underlying
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摘要 fMRI在脑生理刺激下所测得的信号来自于神经元(谷氨酸盐的释放)与星形胶质细胞(糖酵解)之间代谢和信号的交换,这是脑功能成像技术的细胞学和分子学理论基础。 The signals detected during physiological activation in humans with fMRI may result from signaling and metabolic exchanges between neurons(glutamate release)and astrocytes(glycolysis),which provides a cellular and molecular basis for these functional brain imaging techniques.
作者 张俊海 冯晓源 黎元 汤伟军 姚振威
机构地区 复旦大学附属华山医院放射科
出处 《中国医学计算机成像杂志》 CSCD 2004年第5期319-323,共5页 Chinese Computed Medical Imaging
关键词 功能磁共振成像 能量代谢 脑功能成像技术 谷氨酸盐 星形胶质细胞 分子学 MRI 信号 交换 Brain Energy metabolism Functional magnetic resonance imaging
分类号 R445.2 [医药卫生—影像医学与核医学]
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参考文献19

  • 1Hatazawa J, Ito M, Matsuzawa T, et al. Measurement of the ratioof cerebral oxygen consumption to glucose utilization by positron emission tomography: its consistency with the values determined by the Kety - Schmidt method in normal volunteers. J Cereb Blo
  • 2Pellerin L, Pellegri G, Martin JL, et al. Expression of monmcarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs.Adult brain. Proc Natl Acad Sci USA 1998; 95:3990 ～ 3995
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  • 5Kennedy C, Des Rosiers MH, Sakurada O, et al. Metabolic mapping of the primary visual system of the monkey by means of the autoradiographic [14C] deoxyglucose technique. Proc Natl Acad Sci USA 1976; 73:4230 ～ 4234
  • 6Sappey - Marinier D, Calabrese G, Fein G, et al. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 13p magnetic resonance spectroscopy. J Cereb Blood Flow Metab 1992; 12:584 ～ 592
  • 7Pellerin L, Magistretti PJ. Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+ / K +ATPase. Dev Neurosci 1996; 18:336 - 342
  • 8Pellerin L, Magistretti PJ.Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Pro Natl Acd Sci USA 1994; 91:10625- 10629
  • 9Pellerin L, Magistretti PJ. Glutamate uptake stimulates Na+ , K +- ATPase activity in astrocytes via activation of a distinct subunit highly sensitive to ouabain. J Neurochem 1997; 69:2132 -2137
  • 10Prichard J, Rothman D, Novotny E, et al. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Med Sci 1991; 88:5829 - 5831

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中国医学计算机成像杂志
2004年 第5期

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