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细胞周期蛋白E及其与乳腺癌预后关系的研究近况 被引量：2

Cyclin E and Its Relationship with the Prognosis of Breast Cancer
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摘要 细胞周期的失控是造成癌细胞恶性增殖及其他特征的主要原因之一 ,而细胞周期蛋白E (CyclinE)在细胞周期中是一种重要的促使细胞进入S期的调节因子 ,它在肿瘤尤其是恶性肿瘤的发生发展过程中起着重要的作用。近年来 ,研究者们认为CyclinE有评估乳腺癌预后的潜力。越来越多的证据表明 ,Cy clinE和其他生物学指标相比 ,它与乳腺肿瘤预后的相关性更大。而CyclinE能否成为较传统的临床病理参数更好的肿瘤分层评估指标尚有待进一步研究。 The disordered cell cycle regulation contributes to malignant proliferation and other characteristics of cancerous cells. The Cyclin E is an important regulatory factor promoting cells to enter the S phase. It plays an important role in the tumorigenesis and development of tumors (especially malignat ones). In recent years, researchers believe that Cyclin E has the potential to be used for assessing the prognosis of breast cancer. More and more evidence show that cyclin E bears stronger correlation with the prognosis of breast cancer than the other biomarkers. But whether Cyclin E is a better indicator awaits further study.
作者 何文山 黄韬
机构地区 华中科技大学同济医学院附属协和医院普通外科
出处 《医学分子生物学杂志》 CAS CSCD 2004年第5期292-294,305,共4页 Journal of Medical Molecular Biology
基金 卫生部优秀青年人才科研基金 (No .970 2 8)
关键词 细胞周期蛋白E 预后 乳腺癌 研究近况 肿瘤 恶性增殖 发生发展 生物学指标 调节因子 cyclin E breast cancer prognosis
分类号 R737.9 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
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参考文献21

  • 1Han S, Park K, Bae BN, et al. Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kipl expression on tissue microarrays of node negative breast cancer. J Surg Oncol, 2003, 83 (4): 241-7.
  • 2Lindahl T, Landberg G, Ahlgren J, et al. Overexpression of cyclin E protein is associated with specific mutation types in the p53 gene and poor survival in human breast cancer.Carcinogenesis, 2004, 25 (3): 375-80.
  • 3Foulkes WD, Brunet JS, Stefansson IM, et al. The prognostic implication of the basal-like (cyclin E high/p27low/p53 +/glomeruloid-microvascular-proliferation + )phenotype of BRCAl-related breast cancer. Cancer Res,2004, 64 (3): 830-5.
  • 4Christov K, Ikui A, Shilkaitis A, et al. Cell proliferation,apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors.Breast Cancer Res Treat, 2003, 77 (3): 253-64.
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  • 7[ No Author List ] New test may predict survival from breast cancer. Mayo Clin Womens Healthsource, 2003, 7(4): 3.
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  • 9Keyomarsi K, Tucker SL, Buchholz TA, et al. Cyclin E and survival in patients with breast cancer. N Engl J Med,2002, 347 (20): 1 566-75.
  • 10Rudolph P, Kuhling H, Alm P, et al. Differential prognostic impact of the cyclins E and B in premenopausal and postmenopausal women with lymph node-negative breast cancer. Int J Cancer, 2003, 105 (5): 674-80.

同被引文献22

  • 1何文山,黄韬,王海久.Cyclin E在乳腺癌组织中的表达及其与乳腺癌预后的关系[J].华中科技大学学报（医学版）,2004,33(3):304-307. 被引量：3
  • 2[1]WU Z Y,ZHEN L L,FAN P.Mutation analysis in the BRCA1 gene in chinese breast cancer families[J].Chinese-German J Clin Oncol,2003,2:153-155.
  • 3[2]MARTIN M.Molecular biology of breast cancer[J].Clin Transl Oncol,2006,8:7-14.
  • 4[3]SUTHERLAND R L,MUSGROVE E A.Cyclin E and prognosis in patients with breast cancer[J].N Engl J Med,2002,347:1546.
  • 5[6]KEYOMARSI K,OLEARY N,MOLNAR G,et al.Cyclin E,a potential prognostic marker for breast cancer[J].Cancer Res,1994,54:380-385.
  • 6[7]MUMBERG D,HAAS K,M r y T,et al.Uncoupling of DNA replication and cell cycle progression by human cyclin E[J].Oncogene,1996,13:2493-2497.
  • 7[8]KEYOMARSI K,TUCKER S L,BUCHHOLZ T A,et al.Cyclin E and survival in patients with breast cancer[J].N Engl J Med,2002,347:1566-1575.
  • 8[9]MORRIS K V.Therapeutic potential of siRNA-mediated transcriptional gene silencing[J].Biotechniques,2006,Suppl:7-13.
  • 9李治,刘春萍,贺艳丽,张景辉,黄韬.乳腺癌干细胞BCRP的表达及意义[J].医学分子生物学杂志,2007,4(6):511-513. 被引量：4
  • 10BAUER K R, BROWN M, CRESS R D, et al. Descriptive analysis of estrogen receptor (ER) -negative, progesterone receptor (PR)-negative, and HER-2-negative invasive breast cancer, the so-called triple-negative phenotype : a population based study from the california cancer registry [ J]. Cancer,2012,109 (9) : 1721-1728.

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医学分子生物学杂志
2004年 第5期

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