白细胞介素-6在心脑血管病中的临床意义

Clinical Significance of Measurements of Serum IL-6 Levels in Patients with Cardiovascular and Cerebrovascular Diseases

目的 :观察心血管疾病患者白细胞介素 - 6 (IL - 6 )水平的变化 ,探讨IL - 6对冠心病、高血压和脑梗死的临床意义。方法 :采用放射免疫分析检测 35例冠心病、2 0例高血压和 2 8例脑梗死患者血清IL - 6的水平 ,并与 30例正常对照进行对比分析。结果 :冠心病和脑梗死患者IL - 6水平都高于正常对照组 (P <0 0 5 ) ,而高血压患者IL - 6水平与正常对照组相比无显著性差异 (P >0 0 5 )。结论 :检测血清IL - 6的水平对诊治冠心病和脑梗死患者有一定的临床意义。

Objective To explore the clinical significance of changes of serum IL-6 levels in patients with cardiovascalar and cerebrovascular diseases. Methods Serum IL-6 levels were determined with RIA in 35 patients with coronary heart disease, 20 patients with essential hypertension, 28 patients with cerebral infarction and 30 controls. Results Serum IL-6 levels in patients with coronary heart disease and cerebral infarction were significantly higher than those in the controls (P<0.05), while levels in patients with essential hypertension were not much different from those in controls (P>0.05). Conclusion Serum IL-6 levels changes could reflect the severity of the inflammatory process and would be belpful in clinical assessment.