脑外伤患者血清和脑脊液NSE测定的临床意义

Clinical Significance of Determination of Serum and Cerebro-Spinal (CSF) Fluid Levels of Neuron Specific Enolase (NSE) in Patients with Brain Injury

目的 :探讨了颅脑外伤患者血清和脑脊液神经元特异性烯醇化酶 (NSE)的水平及其临床意义。方法 :采用放射免疫分析对 36例颅脑外伤患者进行了血清和脑脊液NSE测定。结果 :颅脑外伤患者血清和脑脊液NSE水平均显著地升高 ,尤以重型组为甚。结论 :测定颅脑外伤患者血清和脑脊液NSE水平对了解病情 ,并有助于判断愈后。

Objective To explore the clinical significance of determination of serum and CSF levels of NSE in patients with brain injury. Methods Serum and CSF levels of NSE were determined with RIA in 36 patients with brain injury. Results Serum and CSF levels of NSE increased markedly in patients with brain injury, especially in severe cases. Conclusion NSE levels (both in serum and CSF) is a practical prognostic parameter in patients with brain injury.