麻疹患者血清SIL-2R和T淋巴细胞亚群的相关性探讨

Study on the Relationship Between Serum Soluble IL-2 Receptor (sIL-2R) Concentration and Distribution Pattern of Peripheral Blood T-Cell Subsets in Patients with Measles

目的 :探讨了血清可溶性白细胞介素 - 2受体 (SIL - 2R)和T淋巴细胞亚群在麻疹感染中的作用。方法 :应用双抗体夹心ELISA法和单克隆抗体法对 37例麻疹患者进行了血清SIL - 2R和T淋巴细胞亚群测定 ,并以 35例正常人作对照。结果 :麻疹患者在出疹期血清SIL - 2R水平显著地高于正常人组 (P <0 0 1) ,至恢复期虽然血清SIL - 2R水平有所下降 ,但与正常人组比较仍有显著性差异 (P <0 0 1)。SIL - 2R水平与T淋巴细胞亚群中CD8细胞比值密切相关。结论 :检测麻疹患者血清SIL - 2R和T淋巴细胞亚群水平可作为患者病情变化、预后判断的重要检测指标。

Objective To investigate the serum sIL-2R concentration and T-cell subsets distribution pattern in patients with measles. Methods Serum sIU-2R levels (with ELISA) and peripheral blood T-cell subsets distribution pattern (with mono-clonal antibody technique) were determined in 37 patients with measles and 35 controls. Results Serum sIL-2R levels in measle patients during eruption were significantly higher than those in controls (P<0.01). The serum levels dropped during convalescence, but still remained significantly higher than those in controls (P<0.01). Serum sIL-2R levels were positively correlated with CD 4/CD 8 ratio. Conclusion Data from this study were compatible with the theory that the disease mechanism of measles might be related to a systemic delayed type of super-hypersensitive cellular immune response.