肌钙蛋白I在不稳定型心绞痛中的临床意义

Clinical Significance of Serum Cardiac Troponin I (cTnI) Levels in Patients with Unstable Angina Pectoris (UAP)

目的 :探讨不稳定型心绞痛 (UAP)病人的血清肌钙蛋白I(cTnI)水平与心绞痛分级 ,短期心脏事件发生率的关系。方法 :6 4例UAP患者 ,30例健康对照组进行了血清cTnI测定 ,并观察了 30d的心脏事件发生率。结果 :UAP组血清cTnI值明显高于健康对照值 (P <0 0 1) ,UAP组内随着Braunwald临床分级增高 ,血清cTnI值亦相应增高 (P <0 0 5 ) ,同时UAP组内cTnI阳性组 (≥ 0 0 4ng/ml)短期心脏事件发生率明显高于cTnI阴性组 (<0 0 4ng/ml) (P <0 0 1)。 结论 :血清cTnI与UAP的严重程度相关 ,并对短期心脏事件的预测有着重要的临床意义。

Objective To investigate the serum cardiac troponin I (cTnI) level in UAP patients of different grades and its applicability for predicting short-term incidence of cardiac events. Methods Serum cTnI levels were determined with sandwich ELISA in 64 UAP patients of different grades and 30 controls. cardiac events wihtin 30 days were noted. Results Serum cTnI levels in UAP patients were significantly higher than those in the controls (P<0.01). The levels increased with advancing Braunwald grading (Ⅰ-Ⅳ); differences between values in successive grades were significant (both P<0.05). Incidence of short-term cardiac events was significantly higher in patients with serum cTnI values above 0.04ng/ml than that in patients with levels below 0.04ng/ml (13/28, 46.4% vs 4/36, 11.10%, P<0.01). Conclusion Serum levels of cTnI in patients with UAP was closely related to the severity of the disease and was of important clinical value for predicting occurrence of cardiac events.