胃癌微血管密度与其生物学行为的关系

The Relationship between Microvasculardensity and Biological Behavior in Gastric Carcinoma

目的 :探讨胃癌组织中微血管密度 (MVD)和临床病理因素的关系。方法 :采用免疫组织化学S P法检测 2 0例正常胃黏膜及 80例胃癌组织中MVD。结果 :胃癌组织MVD显著高于正常胃粘膜MVD(41.0 0± 14 .75vsll.5 0± 3.80P <0 .0 1) ,MVD与胃癌组织浸润深度、分化程度、淋巴结转移、远处转移和TNM分期等密切相关 (P <0 .0 1)。结论 :胃癌组织MVD显著增加 ,MVD与胃癌的临床病理特征密切相关 ,MVD可能是临床评价胃癌恶性程度的重要指标。

Objective: To investigate the relation between microvascular density(MVD)and the clinicopathologic characters of gastric carcinoma.Methods:MVD was examined with immunohistochemical S P method in 20 specimens of normal gastric mucosa and 80 specimens of gastric carcinoma.Results:The MVDs in gastric carcinomas were higher than that in normal gastric mucosa(41.00±14.75 vs 11.50±3.80 P <0.01).The MVD was significantly related with the depth of the tumor invasion,histological differentiation,lymph node metastasis,distant metastasis,and TNM stage( P <0.01).Conclusion:The MVD is significantly increased in qastric carcinoma.The MVD is well associated with the clinicopathologic characters of gastric carcinoma.It may be valuable to evaluate the malignant degree of the gastric carcinoma.