1LevineAJ,Monand J,Finlay CA,et al. The p53 tumor suppressor gene[J]. Nature,1991,351:453～456.
2Frank-JL, BurMe, GarbJL, et al. p53 tumor suppressor oncogene expression in sqnamous all carcinoma of the hypopharynx [J]. Cancer,1994,73(1) :181～186.
3Ahomadegbe-JLBarrois, M, Fogel, S, et al. High incidence of p53 alterations in head and neck pnimary tumor and metastases;Absence of correlation with clinical outcome. frequent protein over expression in normal epithelium and in earvy non-invasive lesions[J]. Oncogenee, 1995,10(6 ) :1 217～1 227.
4Roth JA. Modification of tumor suppressor gene expression in non-small cell lung cancer(NSCLC)with a retrovical rector expressing wild type cnormal p53[J]. Hum gene Ther, 1996,7:861～874.
6Bischoff JR,Kirn DH;Willians A,et al. An adenovirus mutant that replicates selectively in p53-deficicient human tumor cells [J]. Science,1996,274:373.
7Khuri,NemumaitisJ,Ganly I,et al. Acontrolled trial of intratumoral )NYX-015, a selectively-replicating adenovirus, in combination with cisplatiaa and 5-fluorouracil in patsents with recurrent head and neck cancer[J]. Nature Medicine, 2000,6:879～885.
8Liu TJ,Zhang Ww,Tavylor DL,et al. Growith suppression of human head and neck cancer cells by the introduction of a wild type p53 gene via a recombinant adenovirus[J] . Cancer Res,1994,54:3 662～3 667.
9Clayman GL,el al. Naggar AK,Roth JA,et al. In vivo molecular therapy with p53 adenoviral for microscopic residualhead and head squamous carcinoma[J]. Cancer Res, 1995,55: 1～6.
10Liu TJ, el-Mafgar AK, MC Donnell TJ, et al. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck[J]. Cancer Res,1995,55:3 117～3 122.
