吡喹酮治疗慢性日本血吸虫病198例副作用观察

Treatment of Chronic Japonica Sehistosoma with Praziquantel Observing the Side Effects of 198 Cases

观察近10年来以吡喹酮治疗慢性日本血吸虫病198例的副作用,发现副作用出现率为77.28%(153/198).其主要表现为头昏38.9%(77/198)、失眠28.8%(57/198)、多梦16.2%(32/198)、乏力13.2%(26/198)、眩晕13.2%(26/198),还有肝区痛、腹痛等。部分患者肝功能及心脏功能受到一定的影响,提示治疗过程中,对心动过缓者宜严密观察。此外,还对患者住院时间及夹杂症患者的治疗进行了讨论。

By observing the side effect of praziquantel which was used for treating 198 cases of chronic Japonica schistosoma (1981～1991),we found the rate of the side effect was 77.3% (153/198). The main symyptoms were giddiness (38.9%,77/198),insomnia (28,8%,57/198),dreaminess (16.2%,32/198),tiredness (13.2%,26/198),vertigo (13.2%,26/198),and pain in the liver area,diarrhoea.There were also effects on the functions of liver and heart in some patients to certain extent.The results suggested the serious observation should be given in those who had bradyrhythmia. In addition,the complications and administrating time were discussed.