摘要
药物敏感场效应晶体管(DrugFET)是离子敏感场效应晶体管(ISFET)和药物敏感膜相结合的产物。本文研究了药物敏感膜的组成和配比,探讨了成膜的最佳条件,并对一些成膜体系对药物的响应性能进行了研究。以β-环糊精为电活性物质,邻苯二甲酸二辛酯为增塑剂制成药物敏感膜,对麻黄碱的响应范围为1.0mol/L~4.0×10-5mol/L,斜率为58.0mV/pC,适宜pH范围为4.5~8.0。用其分析麻黄碱片剂含量,分析结果和药典方法相一致。
he constitution,mixed ratio,and optimum conditions of preparing ephedrine sensitive membranes are studied.The membrane is prepared with β-CD as electric active material, dioctyl(o-)phthalate as plasticezer. It exhibits Nernst response for ephedrine cation with a slope of 580mV/decade over the concentration ranges of 10mol/L~40×10-5mol/L at pH 45~ 80. It has been used for the determination of ephedrine in medicinal tablet .The results obtained agree with the pharmacoeia method.
出处
《宝鸡文理学院学报(自然科学版)》
CAS
1998年第3期28-31,共4页
Journal of Baoji University of Arts and Sciences(Natural Science Edition)
基金
陕西省科学基金
关键词
离子敏感场效应晶体管
药物敏感膜
药物分析
Ion sensitive field effect transitor Drug sensitive membranes Drug analysis