胸腺肽治疗骨结核T淋巴细胞亚群变化的临床研究

Clinical study of the changes of T-lymphocyte sub-populations with the application of thymus peptide in the treatment of bone tuberculosis

目的 :观察胸腺肽在骨结核治疗过程中T淋巴细胞亚群的变化 ,以期了解胸腺肽对于结核患者免疫功能的影响。方法 :将 74例骨结核患者在正规抗结核治疗的基础上随机分为治疗组 (加用胸腺肽组 )、对照组 ,同时进行两组患者的T淋巴细胞亚群的动态检测。将所得数据进行统计分析 ,采用SPSS11 5统计软件进行数据处理。结果 :经 3个月的治疗后 ,对照组T淋巴细胞亚群的改变与治疗前差异无显著性。而治疗组CD3+ 及CD4 + 升高、CD8+ 降低、CD4 + /CD8+ 比值增高 ,均具有统计学意义(P <0 0 1)。结论 :胸腺肽对于骨结核患者免疫功能有一定的调节功能。

Objective:To observe the change of T-lymphocyte sub-populations with the application of thymus peptide in the treatment of the patients with bone tuberculosis and to evaluate the effect of thymus peptide on immunity function of the patients.Methods:74 patients were divided into therapy group(addition of thymus peptide group)and control group.Every patient was received the normal anti-TB treatment.In the initiation and end of the therapy,the variation data about T-lymphocyte sub-populations were checked and recorded.All data were analyzed with the statistical software of SPSS11.5.Results:After three months,the changes of T-lymphocyte subsets in control group had no significant difference compared with pre-treatment.However,in therapy group CD3 +,CD4 + and CD4 +/CD8 + increased and CD8 + decreased compared to the pre-treatment ( P <0.01).Conclusion:The application of thymus peptide can adjust immunity function effectively in bone tuberculosis patient.