摘要
目的 :观察兔泪道电灼后的愈合过程及易贝滴眼液 (重组人表皮生长因子滴眼液 )对愈合的影响 ,探讨灼通术后的复发机制。方法 :制造鼻泪管电灼模型 ,设立基础对照组、配对设计对照组、治疗组 ,观察各组术后临床变化、鼻泪管组织的病理变化、分层计数增殖细胞核抗原 (PCNA)阳性率 ,并作统计分析。结果 :①术后第 6天 ,泪道已恢复导泪功能 ,荧光素试验阳性时间较基础对照组短。②上皮层具有强大的再生能力 ,术后 5～ 7d后已全部覆盖电灼区 ,鼻泪管的组织结构基本恢复约需 14d。③易贝滴眼液能促进上皮层及间质层的愈合 ,能促进间质层纤维细胞增殖率的恢复。结论 :应用易贝滴眼液能促进鼻泪管电灼术后的愈合 ,间质层收稿日期 :2 0 0 3 -12 -0 3 ;修回日期 :2 0 0 4-0 4-2 5作者简介 :胡文学 ( 1973 -) ,男 ,湖北麻城人 ,医学硕士 ,研究方向 :白内障、泪道病等。E -mail:yankehwx@yahoo.com .cn的长期过度增殖可能是鼻泪管阻塞复发的主要原因。
Objective:To observe the healing process in rabbits after performing high-frequency electric lacryocystoplasty(HFEL) and the effect of rhEGF eye drops. To study recurring processes after performing HFEL.Methods:A postoperative model of HFEL was created in rabbits. There were three groups:the background group,the pair-matching design control and the interference group. The postoperative clinical status and pathological changes in the naso-lacrimal duct were assessed. The positive cell rate of the proliferating cell nuclear antigen(PCNA) was counted by layer.Results:①6 days postoperatively,the lacrimal duct had recovered functioning as a passage. The time interval for a positive result on the fluorescein disappearance test(FDT) was shorter than for the background group.②The epithelium showed a great ability to regenerate;the wound region could be covered with epithelia in 5 to 7 days postoperatively but the basic histological structure of the naso-lacrimal duct required 14 days for recovery.③rhEGF eye drops facilitated the healing of the epithelial and interstitial layers,and accelerated the recovery of fibrocyte proliferation.Conclusion:rhEGF eye drops can facilitate the healing of the naso-lacrimal duct after HFEL treatment. Interstitial layers proliferating over a long period of time may be the prime cause of recurrence.[
出处
《眼视光学杂志》
CAS
2004年第3期161-164,共4页
Chinese Journal of Optometry & Ophthalmology
