碱性成纤维细胞生长因子和转化生长因子-β在实验性近视中的研究进展

bFGF and TGF-β in experimental myopia

bFGF(碱性成纤维细胞生长因子 ,basicfibroblastgrowthfactor)和TGF β(转化生长因子 β ,transforminggrowthfac tor β)是体内分布广泛、具有多种生物学功能的两种细胞因子。近年的研究发现 ,实验性近视发生发展过程中视网膜及巩膜的bFGF和TGF β含量发生改变 ,而外源性的bFGF和TGF β也可影响近视的形成 ,表明bFGF和TGF β与近视具有密切的关系。其可能的机制为 :在异常的视觉环境中 ,视网膜上的bFGF和TGF β含量发生变化 ,作为信号 ,传递到巩膜 ,进而影响巩膜细胞的增殖及细胞外基质的降解 ,使巩膜重新塑形 ,眼轴过度延长 ,形成近视。本研究就这两种生长因子和近视的相关研究做一论述。

Myopia is based on an excessive elongation of the eye that mainly results from the active extension of the sclera. bFGF(basic fibroblast growth factor) and TGF-β(transforming growth factor-beta) are possible molecular signals involved in the occurrence and development of myopia. However,the mechanisms are still unclear. They may regulate scleral thickness by controlling the degradation of the extracellular matrix and influencing the growth of scleral cells. This paper summarizes the progress of research in this field and the role of these growth factors in the signaling that takes place between molecules in the retina and sclera during ocular elongation.[