CB在98例乳腺癌中的表达与临床及病理分析

The analysis of the expression and clinical significance of CB in tissue with 98 cases of breast carcinoma

目的 研究乳腺癌组织中组织蛋白酶 B(CB)的表达及其与肿瘤浸润转移的关系 ,揭示乳腺癌的浸润转移机制。方法 应用 S- P免疫组化方法检测 98例乳腺癌组织和 30例乳腺非癌组织中 CB的表达情况及其与临床病理参数的关系。结果 在 98例乳腺癌组织中 ,CB实质阳性表达率为 74 .5 % (73/ 98) ,与良性对照组比较有显著差异 ;乳腺癌实质中 CB的阳性表达与淋巴结转移及 TNM分期密切相关 ;而与年龄、肿瘤大小、病理组织学类型、病理分级无关。结论 乳腺癌实质中 CB的阳性表达与肿瘤的浸润转移密切相关 ,而且可能是预测乳腺癌预后的一个独立的生物学指标。

Objective To investigate the expression of Cathepsin B(CB)in the breast carcinoma tissue,to find out their relationship with tumor invasion and metastasis,to disclose the mechanism of the tumor invasion and metastasis of breast carcinoma.Methods Tissues were obtained from 98 patients with breast carcinoma and 30 without breast carcinoma.The expression of CB was examined by immunohistochemical technique(streptavidin-peroxidase conjugate method,S-P),and the results were correlated with clinicopathological tumor parameters.Results The positive incidence of CD expression in 98 cases of breast carcinoma was 74.5%(73/98),which differentiate apparently that of the control group.The expression of CB in cancer cells were related to axillary lymph node metastasis and TNM stage,and the expressions of CB were not related to age,tumor size,histologic type and histologic grade.Conclusion The expression of CB in cancer cells is closely related to the tumor invasion and metastasis of breast carcinoma,which suggests that it is an useful prognostic indicator for breast carcinoma.