符合线路显像在大肠癌术后复发转移中的临床应用

Study of clinical application of ^(18)F-FDG SPECT with coincidence in the recurrent or metastatic tumor of colorectal carcinoma

目的 探讨符合线路显像在大肠癌术后复发转移中的临床应用价值。方法 对 31例临床怀疑复发转移的大肠癌术后患者行1 8F 脱氧葡萄糖 (FDG)符合线路显像 ,计算其诊断准确性、灵敏度、特异性、阳性预测值、阴性预测值及其 95 %可信区间 ,并与B超、CT、MRI的诊断结果相比较。结果 31例大肠癌术后患者中显像阳性 19例 ,假阴性 2例 ,无假阳性。其诊断准确性、灵敏度、特异性、阳性预测值、阴性预测值分别为 93 5 % ,90 5 % ,10 0 % ,10 0 % ,83 3% ;其 95 %可信区间为 78%～99% ,70 %～ 99% ,6 9%～ 10 0 % ,82 %～ 10 0 % ,6 9%～ 10 0 %。符合线路显像的诊断准确性明显高于B超和CT ,灵敏度和阴性预测值明显高于B超 ;95 %可信区间分析结果示符合线路显像高于B超、CT和MRI。结论 1 8F FDG符合线路显像对大肠癌术后复发转移的诊断有较高的临床应用价值。

Objective To investigate the clinical value of 18 F-fluorodeoxyglucose (FDG) SPECT with coincidence in the diagnosis of recurrent or metastatic tumor of colorectal carcinoma. Methods Thirty-one cases of postoperative patients with colorectal cancer were enrolled in this study with 18 F-FDG SPECT with coincidence. The results were analyzed by calculating its accuracy,sensitivity,specificity,positive predictive value (PPV),negative predictive value (NPV),95% confidence interval and compared with US,CT and MRI. Results In 31 cases of postoperative patients with colorectal cancer in this study,there were 19 positive cases,and 2 false negative cases. There was no false positive case. The accuracy,sensitivity,specificity,PPV and NPV were 93.5%,90.5%,100%,100%,83.3%,respectively,and their 95% confidence interval were 78%～99%,70%～99%,69%～100%,82%～100%,69%～100%,respectively. The diagnostic accuracy of 18 F-FDG SPECT was higher than that of CT and US,and the sensitivity and NPV were significantly higher than that of US. The analysis of 95% confidence interval showed a higher tendency in 18 F-FDG SPECT than in US,CT and MRI. Conclusion 18 F-FDG SPECT has high clinical value in the diagnosis of recurrent or metastatic tumor of colorectal carcinoma.