β射线局部照射对冠状动脉弥漫性支架内再狭窄的疗效

Clinical effects of intracoronary brachytherapy on diffuse in-stent restenosis after coronary angioplasty

目的 探讨 β射线 (90 Sr 90 Y)对冠状动脉 (简称冠脉 )弥漫性支架内再狭窄的疗效。方法 39例经皮冠脉介入术 (PCI)及支架置入术后支架内再狭窄患者 ,随机分为支架内放射治疗组 (治疗组 ) 18例及单纯球囊组 (对照组 ) 2 1例。 2组患者再狭窄病变先经充分球囊扩张 ,治疗组用Beta Cath系统进行冠脉内放射治疗。术后随访 9个月。结果 治疗组 1例 (5 6 % )研究段血管再狭窄 ,对照组有 8例 (38 1% )再狭窄 ,两组间差异有显著性 (P =0 0 0 6 )。结论 β射线治疗冠脉弥漫性支架内再狭窄安全、有效、可行。

Objective To investigate the effect of intracoronary brachytherapy using 90 Sr/ 90 Y on in-stent restenosis in patients with coronary disease. Methods Thirty-nine patients (male 29 ,female 10) with in-stent restenosis after percutaneous coronary intervention (PCI) were studied. The patients were divided randomly into two groups: single-balloon group(21 cases,control group) and brachytherapy group(18 cases,treatment group). All the lesions were treated with balloon angioplasty satisfactorily. After that the patients in treatment group took a brachytherapy using the Beta-Cath system(Novoste). After the operation,there was a 9-months follow-up. Results Within the follow-up,one case (5.6%) in treatment group was found to be with in-stent restenosis and 8 cases(38.1%) in control group. There was significant difference between the two groups(P=0.006). Conclusion The brachytherapy using 90 Sr/ 90 Y after balloon angioplasty is safe,effective and feasible for containing diffuse in-stent restenosis in patients.