慢性乙型肝炎干扰素疗效与人类白细胞抗原-等位基因的关系

Association between efficacy of interferon and HLA alleles in the patients with chronic viral hepatitis B

目的 探讨慢性乙型病毒性肝炎干扰素 α治疗 6个月疗效与人类白细胞抗原 (HLA)部分等位基因的关系。方法 应用聚合酶链反应 序列特异性引物 (PCR SSP)技术对 6 0例上海地区接受干扰素 α正规治疗 6个月的慢性乙型肝炎患者的HLA Ⅱ类分子DRB1、DQA1、DQB1进行等位基因多态性分析。结果 无应答组的HLA DRB1 0 4携带率高于有应答组 (P <0 .0 2 5 ) ,有应答组的HLA DQA1 0 5 0 5 (P <0 .0 2 5 )、DQB1 0 30 1(P <0 .0 0 5 )的携带率高于无应答组。结论 干扰素 α治疗无应答与HLA DRB1 0 4 (P <0 .0 2 5 )呈正相关 ,与HLA DQA1 0 5 0 5、HLA DQB1 0 30

Objective To study the association between efficacy of interferon α and some HLA alleles. Methods Sixty patients with chronic viral hepatitis B in Shanghai were subjected to a standard course of treatment with interferon α for six months. HLA DRB1, DQA1, DQB1 alleles were detected by using the polymerase chain reaction sequence specific primer(PCR SSP) technique. Results The frequency of HLA DRB1 *04 in non responders was higher than that in responders( P <0.025) and the frequencies of HLA DQA1 *0505( P <0.025) and HLA DQB1 *0301( P <0.005) in responders were higher than those in non responders. Conclusions No response of interferon α therapy was correlated positively with HLA DRB1 *04 and correlated negatively with HLA DQA1 *0505,HLA DQB1 *0301 in the patients with chronic viral hepatitis B.