血总胆固醇与红细胞变形性测定及其关系探讨

The relation between total cholesterol in plasma and RBC deformability

目的 :探讨血浆总胆固醇浓度与红细胞变形性两者的关系。方法 :胆固醇测定用终点酶法全自动生化分析 ,红细胞变形性用激光衍射法。结果 :Y=3 78.0 6-1 9.3 0 X,r=-0 .5940 ,P<0 .0 5。血浆总胆固醇浓度与红细胞变形性呈真性负相关。结论 :说明胆固醇不但是形成动脉粥样硬化的重要因素 ,同时也是影响红细胞变形性的重要因素 ,而红细胞变形性减小可导致局部血流不畅甚至血栓等心脑血管疾病的发生。

Objective: Cholesterol is an important component of RBC membranous layer which affects RBC deformability. This study is to explore the relation between total cholesterol in plasma and RBC deformability. Methods: Cholesterol was tested by automation biochemistry analysis, and RBC deformability by laser diffraction method. Results: Y= 378.06-19.30X r=-0.5940 P<0.05. Conclusion: Total cholesterol in plasma and RBC deformbility are negatively correlated. Decrease of RBC deformability can be a risk factor for heart and brain diseases.