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内皮祖细胞与他汀类药物调脂外心血管保护作用 被引量：8

Endothelial Progenitor Cells and the Additional Cardiovascular Protective Activity of Statins that Independent of Cholesterol Reduction
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摘要 他汀类药拥有独立于降脂外的多项心血管保护作用。最近的几个研究表明 ,他汀促进内皮祖细胞 (EPCs)的动员、存活、迁移和分化 ,抑制EPCs衰老并促进其增殖 ,上调EPCs整合素的表达引导其黏附 ,从而促进血管新生 ,修复损伤内膜。本文回顾了内皮祖细胞研究概况 ,详细综述了国外关于他汀与内皮祖细胞研究的新进展。 Statins possess an additional cardiovascular protective activity independent of cholesterol reduction.Recent datas show that statins promotes the survival,migration and differentiation of endothelial progenitor cells,reduce senescence and increase the proliferation of EPCs,induce adhesiveness of cultured human EPCs by upregulation of the integrin subunits of human EPCs,thus promote angionesis,accelerates re-endothelialization after carotid balloon injury.This paper reviews the available data on this field.
作者 季亢挺 张怀勤
机构地区 温州医学院附属第一医院
出处 《心血管病学进展》 CAS 2004年第5期360-362,共3页 Advances in Cardiovascular Diseases
关键词 内皮祖细胞 心血管保护作用 他汀类药物 调脂 内膜 血管新生 动员 黏附 分化 存活 endothelial progenitor cells statins cholesterol lowering
分类号 R96 [医药卫生—药理学]
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参考文献27

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  • 2Indolfi C,Cioppa A,Stabile E,et al.Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury[J].J Am Coll Cardiol,2000,35:214-221.
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  • 6Dimmeler S,Aicher A,Vasa M,et al.HMG-CoA-reductase inhibitors (statins) increase endothelial progenitor cells via the PI3 kinase/Akt pathway[J].J Clin Invest,2001,108:391-397.
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  • 8Arasaha T,Masuda H,Takahashi T,et al.Isolation of putative progenitor endothelial cells for angiogenesis[J].Science,1997,275:964-967.
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心血管病学进展
2004年 第5期

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