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脑源性神经营养因子对视网膜保护作用的研究进展 被引量：4

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摘要 脑源性神经生长因子(BDNF)是神经细胞存活和分化所必需的营养物质,能通过PI3- K和MEK／ERK等途径保护视网膜神经节细胞和光感受器细胞,促进其生存,并与其它细胞因子有 叠加作用,本文对此作一综述。
作者 蔡春梅 孙葆忱
机构地区 首都医科大学附属北京同仁医院眼科中心北京市眼科研究所
出处 《国外医学（眼科学分册）》 2004年第4期268-271,共4页 Foreign Medical Sciences(Section of Ophthalmology )
关键词 脑源性神经营养因子 保护作用 视网膜神经节细胞 光感受器细胞 研究进展 BDNF ERK 分化 存活 神经细胞
分类号 R77 [医药卫生—眼科]
  • 相关文献

参考文献22

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  • 2Takahata K, Katsuki H, Kume T, et al. Retinal neuronal death induced by intraocular administration of a nitric oxide donor and its rescue by neurotrophic factors in rats. Invest Ophthalmol Vis Sci,2003, 44(4): 1760-1766.
  • 3Wahlin KJ,Campochiaro PA, Zack KJ, et al. Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptor. Invest Ophthalmol Vis Sci, 2000,41:927-936.
  • 4Klocker N,Kermer P, Weishaupt JH, et al. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling. J Neurosci, 2000, 20
  • 5Harris CA, Deshmukh M, Tsui-Pierchala B, et al. Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons. J Neurosci, 2002, 22(1)
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  • 7Hare W, WoldeMussie E, Lai R,et al. Efficacy and safty of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey. Surv Ophthalmol, 2001,45 (suppl 3): S284-S289.
  • 8Lawrence JM, Keegan DJ, Muir EM, et al. Transplantation of Schwann cell line clones secreting GDNF or EDNF into the retinas of dystrophic Royal College of Surgeons rats. Invest Ophthalmol Vis Sci, 2004, 45(1):267-274.
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同被引文献46

  • 1任蕾,牛建军,王一,王仕军,曾玉晓,刘志敏.利用荧光金逆行示踪技术评价视神经不完全损伤后视网膜神经节细胞的存活率[J].眼科新进展,2005,25(1):21-23. 被引量：15
  • 2苏颖,王继群,王峰,山艳春,陈剑,崔浩,徐锦堂.定量大鼠视神经损伤模型的建立[J].中国病理生理杂志,2005,21(6):1242-1245. 被引量：11
  • 3项敏泓,钟一声,张兴儒.灯盏细辛对兔高眼压视网膜神经节细胞活性的作用[J].眼科新进展,2005,25(5):414-416. 被引量：10
  • 4李海龙,李红,韩华云.银杏叶提取物对大鼠慢性高眼压视网膜损伤的保护作用[J].国际眼科杂志,2007,7(2):414-416. 被引量：11
  • 5Morrison JC, Fraunfelder FW, Milne ST, et al. Limbal microvasculature of the rat eye[J]. Invest Ophthalmol Vis Sci,1995,36(3) : 751 - 756.
  • 6Neufeld AH. Nitric oxide:A potential mediator of retinal ganglion cell damage in glaucoma [ J ]. Surv Ophthahnol, 1999,43 ( Suppl1) : S129 - 135.
  • 7I Cohen-Cory S,Escandon E, Fraser SE. The cellular patterns of BDNF and trkB expression suggest multiple roles for BDNF during Xenopus visual system development[ J ]. Dev Biol,1996,179:102 - 115.
  • 8Duprey-Diaz MV ,Solo 1, Blagburn JM, el al. Changes in brain-derived neurotrophic factor and trkB receptor in the adult Rana pipiens retina and optic tectum after optic nerve injury [ J ]. Comp Neurol, 2002, 454(4) : 456 -469.
  • 9Lee EJ, Song MC, Kim HJ, et al. Brain-derived neurotrophic factor modulates the dopaminergie network in the rat retina after axotomy [ J]. Cell Tissue Res,2005,2: 1 -9.
  • 10Spalding KL,Rush RA, Harvey AR. Target-derived and locally derived neurotrophins support retinal ganglion eell survival in tile neonatal rat retina [ J ]. Neurobio, 2004,60 ( 3 ) : 319 - 327.

引证文献4

二级引证文献7

国外医学（眼科学分册）
2004年 第4期

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