过敏性结膜炎的临床特点

The clinical characteristics of allergic cConjunctivitis

目的 了解各种类型过敏性结膜炎的临床特点。方法 多中心前瞻性研究评价 2 41例过敏性结膜炎患者的病史 ,症状 ,体征等临床评分资料。结果 2 41例过敏性结膜炎中 ,各种亚型分布无明显地区差异 ( χ2 =2 6 699,P =0 14 4,P >0 0 5 )。眼痒和异物感在过敏性结膜炎的症状中发生率最高 (发生率分别为 99%、 80 8% )。结膜充血、上睑结膜乳头和上睑结膜滤泡在过敏性结膜炎的体征中发生率最高 (发生率分别为 93 7%、 88 1%、 78 4% )。季节性过敏性结膜炎 (seasonalaller gicconjunctivitis ,SAC)除季节性发作及症状、体征积分均相对较低外 ,其他临床特点与常年性过敏性结膜炎 ( perennialallergicconjunctivitis ,PAC)十分相似。春季角结膜炎 (vernalkeratoconjunctivitis ,VKC)发病年龄最小 ,伴有典型的上睑结膜乳头改变和高的角膜缘改变发生率 ( 76 7% )。 60 %巨乳头性结膜炎 (giantpapillaryconjunctivitis ,GPC)患者有软性角膜接触镜的配戴史 ,这和其他亚型比较差异有显著性意义 ( χ2 =2 7 689,P =0 0 0 0 ,P <0 0 0 1)。季节性过敏性结膜炎 ,常年性过敏性结膜炎眼痒、异物感两个症状均分别与上、下睑结膜乳头和滤泡相关 (均P <0 0 0 1,r介于 0 2 5～ 0 3 5之间 ) ;春季角结膜炎异物感与?

Objective To understand the clinical characteristics of allergic conjunctivitis.Methods A multicenter,prospective clinical analysis of 241 subjects with allergic conjunctivitis was carried out.Results In 241 subjects with allergic conjunctivitis, there were 69 cases of seasonal allergic conjunctivitis(SAC) (28.6%),106 cases of perennial allergic conjunctivitis(PAC)(43.2%),30 cases of vernal keratoconjunctivitis(VKC)(12.4%),22 cases of atopic keratoconjunctivitis(AKC)(9%),11 cases of giant papillary conjunctivitis(GPC)(4.7%),3 cases were not specifically diagnosed (1.3%).No significant variation was found within each subgroup of allergic conjunctivitis in either the distribution of the regions(χ 2=26.699,P=0.144),or the sex(χ 2=8.956,P=0.111).The primary symptoms of allergic conjunctivitis were itching and foreign body sensation,and the primary physical signs were hyperemia,upper tarsus papilla and upper tarsus follicle.The clinical features of SAC was similar to that of PAC with significant relationship,except for the seasonal attack and more moderate symptoms and signs.The VKC was special of little age,typical upper tarsus papilla and high incidence of corneal limbus change.60% subjects of GPC had history wearing soft corneal contact lens,significantly comparing with other subgroups.Conclusions There may be not sinificant difference in the regional distribution on allergic conjunctivitis in China.The primary symptoms of allergic conjunctivitis are itching and foreign body sensation,and the primary physical signs are hyperemia,upper tarsus papilla and upper tarsus follicle.The symptoms is not parallel to the physical signs in allergic conjunctivitis.