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重组人单核细胞趋化蛋白-1在骨肉瘤化疗过程中的作用 被引量：1

Effect of human recombinant monocyte chemoattractant protein-1 during the course of chemotherapy for osteosarcoma
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摘要 目的　观察重组人单核细胞趋化蛋白 1(MCP 1)在骨肉瘤化疗过程中的作用。方法　建立裸鼠荷人骨肉瘤动物模型。分别及联合应用重组人MCP 1和高剂量氨甲喋呤 (HD MTX)对其进行治疗 ,并设立空白对照。观察瘤体的生长及病理指标。结果　MCP 1可抑制骨肉瘤体的生长 ,但效果不理想 ;HD MTX可明显抑制骨肉瘤体的生长 ,效果显著 ,但可出现肿瘤再生长 ;MCP 1可增强HD MTX对瘤体的抑制作用 ,且能明显延迟肿瘤再生长的时间。结论　重组人MCP 1在骨肉瘤进行HD Objective To observe the effect of human recombinant Monocyte Chemoattractant Protein-1 (MCP-1) during the course of chemotherapy for osteosarcoma. Methods The animal model of human osteosarcoma was established in nude mice. They were given high doses of methotrexate (HD-MTX) or human recombinant MCP-1 alone or combined, and a blank control group was set up. Observations on the growth and pathologic markers of xenotransplanted osteosarcoma were observed and pathological examinations were made. Results MCP-1 inhibited the growth of osteosarcoma, but its effectiveness was not ideal. HD-MTX could inhibit significantly the growth of osteosarcoma, but the tumors could regrow. MCP-1 not only could enhance the tumor inhibition of HD-MTX, but also retard the regrowth of the tumors. Conclusion Recombinant human MCP-1 can enhance significantly the therapeutic effect of HD-MTX on osteosarcoma.
作者 陈宗雄 徐皓 郭葆玉 包聚良 张淑英 贾连顺
机构地区 南京军区福州总医院骨科 第二军医大学药学院生化药学教研室 第二军医大学长征医院骨科 第二军医大学基础部特殊毒理教研室
出处 《上海医学》 CAS CSCD 北大核心 2004年第9期674-676,i002,共4页 Shanghai Medical Journal
基金 福建省青年科技人才创新项目
关键词 骨肉瘤 MCP-1 瘤体 MTX 趋化蛋白 人单核细胞 肿瘤 过程 HD 延迟 Monocyte chemoattractant protein-1 High dose methotrexate Osteosarcoma Nude mice Therapy
分类号 R738.1 [医药卫生—肿瘤]
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参考文献7

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二级参考文献3

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共引文献5

同被引文献11

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引证文献1

上海医学
2004年 第9期

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