埃索美拉唑治疗反流性食管炎的研究

Study of Esomeprazole on reflux esophagitis

目的 探讨埃索美拉唑治疗反流性食管炎的疗效。方法 选择 78例经内镜证实为反流性食管炎的患者 ,给予埃索美拉唑 4 0mg口服 ,每日 1次 ,观察治疗 2 ,4 ,6周时反酸、烧心等症状改善情况 ,并于 6周后复查胃镜。结果 治疗 2 ,4 ,6周症状显效率分别为 5 2 % ,81%及 84 % ,治疗 4及 6周时显效率明显高于治疗 2周时 (P均 <0 0 1)。治疗 6周症状改善总有效率为 92 %。 6周后Ⅰ级食管炎治愈率 (93% )高于Ⅱ级 (76 % )、Ⅲ级与Ⅳ级 (6 7% )(P <0 0 5 ) ,但各级食管炎改善总有效率比较无显著性差异。结论 埃索美拉唑是治疗反流性食管炎的有效药物。

Objective It is to discuss the curative effect of Esomeprazole on reflux esophagitis.Methods 78 patients with reflux esophagitis diagnosed by endoscope were chosen and treated with Esomeprazole 40 mg once a day. The improvements of symptoms including acid regurgitation, heartburn and so on were observed after treated for two, four, six weeks. Endoscope was performed to observe the healing rate after 6 weeks.Results Symptom relief rate were 52%, 81%, and 84% after two, four, six weeks respectively. The rates after four and six weeks were obviously higher than that after two weeks (P<0.05). The total symptom improvement rate was 92% after six weeks. After 6 weeks, the healing rate of type Ⅰ esophagitis (93%) was higher than that of type Ⅱ (76%), type Ⅲ and type Ⅳ (67%) (P<0.05), but there was no significant difference in the total improvement rate among all the types.Conclusion Esomeprazole is an effective medicine to treat reflux esophagitis.