国产齐拉西酮的急性毒性作用的实验研究

Experimental study of acute toxicity of domestic ziprasidone in mice

目的 :研究国产齐拉西酮灌胃 (ig)给予和腹腔 (ip)给药对NIH小鼠的急性毒性反应。方法 :以0 5%羧甲基纤维素钠配制齐拉西酮悬液 ,小鼠灌胃给予和腹腔给予 ,观察指标包括给药后立即和连续14天观察小鼠的一般情况和计算半数致死量(LD50)。结果 :齐拉西酮小鼠灌胃的LD50 大于2 0g/kg。腹腔注射给药的LD50 为1 407g/kg,95%可信限为1 167～1 697g/kg。结论 :对于NIH小鼠 ,齐拉西酮灌胃给药、腹腔给药的LD50 与国外产齐拉西酮的急性毒性相似。

Objective:To study the acute toxicity of domestic ziprasidone administered by gastric infusion and peritoneal injection.Methods:Ziprasidone suspension was respectively administered by gastric infusion and peritoneal injection in NIH mice.The common condition of mice was observed and half of lethal dose(LD 50 )was measured continuously for14days after drug treatment.Results:LD 50 of ziprasidone administered by gastric infusio is beyond20g/kgwt,LD 50 of ziprasidone by peritoneal injection is1.047g/kgwt,and the confidence limit of95%is1.167～1.697g/kgwt.Conclusion:The acute toxicity of domestic ziprasidone is similar with that reported in literature.