肝得宁片中五味子、女贞子提取工艺研究

Studies on extraction process of Fructus Schisandrae Chinensis and Fructus Ligustri Lucidi in Gandening tablet

目的 :为肝得宁片优化五味子、女贞子提取工艺条件。方法 :以五味子甲素转移率和得膏率为主要指标 ,结合工业化生产的可行性 ,对超临界CO2 萃取法、醇提法、水煮法等提取方法进行了比较研究 ,并采用正交设计法优选醇提工艺条件。结果 :3种提取方法以醇提法为佳 ,醇提工艺正交设计优化结果为 :乙醇浓度 90 % ,回流次数2次 ,时间为 1h ,溶媒用量为 6倍。结论 :本工艺稳定可行 ,可为提取五味子。

Objective: To optimize the combined extraction methods of Fructus Schisandrae Chinensis and Fructus Ligustri Lucidi. Method: The extraction effects of three processes (SFE CO_2, alcohol-extraction, water-extraction) were compared by the contents of deoxyschizandrin, the dried extraction yield and production feasibility. Result: The method of alcohol-extraction was the best of the three methods, and the extraction conditions were optimized by orthogonal design as follows: sixfold 90% alcohol for two times and each for one hour. Conclusion: The extraction method is steady and feasible, which can be used for reference for the extraction process of Fructus Schisandrae Chinensis and Fructus Ligustri Lucidi.