卡维地洛与比索洛尔对高血压患者的疗效及对左心室肥厚逆转作用的对比研究

Comparion of Bisoprolol and Carvidilol in Antihypertensive Effects and Reverse Left Ventricular Hypertrophy in Patients with Essential Hypertension

为比较卡维地洛与比索洛尔治疗轻中度高血压病的临床疗效和对左心室肥厚的逆转作用 ,采用随机、单盲、平行对照临床试验方法 ,40例轻中度原发性高血压患者口服安慰剂 2周后舒张压仍在〔1 2 .0～ 1 4.6kPa( 90～ 1 1 0mmHg)〕 ,随机分别给予卡维地洛 ( 1 2 .5～ 2 5mg,qd)和比索洛尔 ( 2 .5～ 5mg ,qd)治疗 ,每组 2 0例 ,疗程为 2 4周。安慰剂期末和治疗过程中测量坐位血压和心率 ,并记录不良反应。在安慰剂期末和治疗 2 4周时做血常规、血生化和心脏超声检查。结果 :2组治疗后患者收缩压、舒张压及心率均有显著下降 (P <0 .0 5～P <0 .0 1 ) ,而 2组间差异不明显。卡维地洛组左室肥厚各项指标均较治疗前明显改善 (P <0 .0 5 ) ,而比索洛尔组治疗前后无明显的统计学差异 ;对血脂、血糖、肝肾功能无显著影响。卡维地洛的不良反应较比索洛尔少且轻微。提示 :卡维地洛治疗原发性高血压疗效确切 ,在降低血压的同时 ,可减轻左心室肥厚 ,改善左心室的舒张功能 。

The aim was to investigate the effects of antihypertension and reverse left ventricular hypertrophy by carvedilol or bisoprolol in patients with mild to moderate essential hypertension. The forty cases of mild to moderate essential hypertension were selected for this random single-blind, paralleling controlled clinical study. Patients were randomized to take 12.5～25 mg carvedilol tablet once daily or bisoprolol 2.5～5 mg once daily if DBP was still in the range of 12.0～14.6 kPa(90～110 mmHg) after 2 week placebo baseline. Carvedilol group included 20 cases, Bisoprolol group included 20 cases, The course was 24 weeks, Blood pressure and heart rate were measured and symptoms and signs were recorded. At the end of placebo and in 24 weeks examined heart ultrasound, blood routine, serum glucose, blood lipid, hepatic function and renal function. SBP, DBP and heart rate of patients in two groups decreased obviously. There were significant differences between the two groups. Ventricular hypertrophy of carvedilol group improved than pretherapy. There were significant differences between the two groups. Carvedilol was well-tolerated with less side effects that concluded mild headache, tiredness, dizziness, slightly elevating of serum Glucose. Carvedilol can well treat the mild moderate essential hypertension effectively and safely by 12.5～25 mg once daily.