深圳市泌尿生殖道解脲支原体和人型支原体感染状况及药物敏感性分析

Detection and evaluation of antibiotic susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in Shenzhen area

目的 了解深圳市泌尿生殖道支原体感染状况及耐药性变化趋势 ,指导临床合理用药。方法 用My coplasmaIST试剂盒对深圳市 2 0 0 2年 84 6 0例泌尿生殖道感染患者 ,取尿道 (宫颈 )分泌物进行了解脲支原体 (Uu)和人型支原体 (Mh)的培养鉴定及药敏检测。结果 Uu单独感染 2 0 6 7例 ,Mh单独感染 5 4例 ,Uu和Mh混合感染 6 78例。男性感染率为 2 7 2 % ,女性感染率为 4 0 2 %。药敏试验显示 :Uu对氧氟沙星的敏感性下降至 36 1% ,Mh对红霉素和四环素的敏感性分别降至 9 3%和 4 8 1% ,原始霉素、交沙霉素对两种支原体都保持稳定的高敏感性。结论 支原体的混合感染、耐药性上升趋势十分严重 ,交沙霉素应作为目前治疗泌尿生殖道Uu和Mh感染的首选 ,支原体耐药性的长期监测是指导临床治疗的重要依据。

Objective To investigate the infections in urogenital tract and changing trend of drug susceptibility of mycoplasma in Shenzhen area. Methods U.ruealyticum(Uu)and M. hominis(Mh)were detected in 8,460 cases with urogenital tract infection,and the susceptibility of clinical strains to antibiotics were determined using Mycoplasma IST kit. Results 2,067 of cases were infected by U.urealyticum,54 cases were infected by M.hominis and 678 cases were positive with both species. 27.2% male were positive and 40.2% of female were positive.Only 36.1% of U u strains were susceptive to ofloxacin. 9.3% and 48.1% of Mh strains were susceptive to erythromycin and tetracycline,respectively. Pristinamycin and josamycin were the most active agents against both species. Conclusion Mixed infection and increasing resistance of mycoplasmas is a serious problem. Multiple resistance to two or more antibiotics were frequent. In view of the susceptibility of M.hominis and U.urealyticum strains to josamycin,it was still the first candidate drug against Uu and Mh. This finding also indicated that resistance monitoring of mycoplasma periodically has important significance in clinical practices.