听神经瘤TGF-β_1的表达及其与肿瘤血管形成的相关性

Expression of TGF-β_1 in Acoustic Neuroma and Its Correlation to Tumor Angiogenesis

目的 探讨人听神经瘤中转化生长因子 β1(TGF β1)和第Ⅷ因子相关抗原 (FⅧRAg)的表达及TGF β1与肿瘤血管形成的相关性。方法 应用免疫组织化学方法检测 69例听神经瘤中TGF β1和FⅧRAg的表达 ,然后进行方差分析和直线相关分析。结果 在实质性组和复发组中 ,TGF β1与微血管密度 (MVD)有明显正相关 ,在囊变组中TGF β1与MVD无相关性。结论 TGF β1、MVD可作为评价听神经瘤生物学行为的客观指标 。

Objective To study the expression of TGF-β_1 and FⅧRAg in human acoustic neuroma and the correlation of TGF-β_1 to tumor angiogenesis.Method Expression of TGF-β_1 and FⅧRAg was detected by immunohistochemistry in 69 cases of acoustic neuroma.Then analyses of variance and linear correlation analysis were carried out.Results In solid and recurrence groups,the correlation of TGF-β_1 to microvascular density(MVD) was positive,and in cystic degenerative group,there was no correlation.Conclusions TGF-β_1 and MVD can be used as objective parameters to evaluate the biological behavior of acoustic neuroma,and can be taken as an important factor to prognosticate the tumor progression and recurrencef.