内皮素系统在肝硬化门脉高压症形成中的作用和地位的研究进展

Research Advance in Function and Role of Endothelin System in the Process of Cirrhotic Portal Hypertension

肝硬化门脉高压症是一个严重影响我国人民健康的常见病 ,在参与门脉压力调节的多种血管活性因子中 ,内皮素系统 (ETS)由于对肝内、肝外血管阻力和门静脉血流量的变化都起着关键作用而备受关注。但是 ,目前对于ETS在肝硬化门脉高压症形成中的作用和地位还存在着诸多争论 ,内皮素受体 (ETR)拮抗剂对门脉高压的血流动力学影响的研究结果也不一致。

The cirrhotic portal hypertension(CPH) is still a severe common disease endangering our health.Among various vascular activation factors,endothelin system(ETS) has received increasing attention due to its pivotal roles in the changes of intrahepatic and extrahepatic vascular resistance and portal blood flow.However,it remains much contravention about the function and status of ETS and effect of endothelin receptor antagonists on hemodynamics of portal hypertension up to now.So,it is necessary that much attention be paied to investigate and evaluate the role and explore the mechanism of ETS in CPH.