1Valero V,Holmes FA,Walters RS,et al.Phase Ⅱ trial of docetaxel:a new,highly effective antineoplastic agent in the management of patients with anthracycline-resistant metastatic breast cancer [J].J Clin Oncol,1995,13(12):2865-2868.
2Knowlton K,Mancini M,Creason S,et al.Bcl-2 shows in vitro breast cancer growth despite its antiapoptotic effect [J].J Surg Res,1998,76(1):22-26.
3Andrulis DC,Bull SB,Blackstein ME,et al.Neu/cerbB-2 amplification identifies a poor prognosis group of women with node-negative breast cancer [J].J Clin Oncol,1998,16(4):1340-1349.
3M Pegram S,Hsu G,Lewis R,et al.Inhibitory effects of combinations of Her-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers[J].Oncogene,1999,18:2241~2251.
4Sliwkowski MX,Lofgren JA,Lewis GD,et al.Nonclinical studies addressing the mechanism of action of Trastuzumab(Hereeptin)[J].Semin Oncol,1999,26(4 Suppi 12):60~70.
5Belselga J.Clinical trial of single-agent Trastuzumab(Herceptin)[J].Semin Oncol,2000,27(5 Suppl 9):20~26.
6Petit AM,Rak J,Hung MC,et al.Neutralizing antibodies against epidermal growth factor and erbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo:angiogenic implications for signal transduction therapy of solid tumors[J].Am J Pathol,1997,151(6):1523~1530.
7Xiao-Feng L,Francois-Xavier C,Amy L,et al.The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody -induced G1 cell cycle arrest and tumor growth inhibition[J].J Biol Chem,2003,278(26):23441~23450.
8Sanskyou L,Wentao Y,Keng-Hsueh L,et al.Enhanced sensitization to taxol-induced apoptosis by Herceptin pretreatment in erbB2-overexpressing breast cancer cells[J].Cancer Research,2002,62:5703~5710.
9Yu D,Jing T,Liu B,et al.Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21 Cip1,which inhibits p34Cdc2 kinase[J].Molecular Cell,1998,2:581~591.
10Iain B,Kawan S,Sarah LM,et al.Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells[J].Breast Cancer,2004,6:601~607.