神经节苷脂联合激素冲击治疗对原发性脑干损伤预后的影响

Therapeutic effects of coordinated therapy of ganglioside and high-dose corticosteroid on prognosis of primary brain stem injury

①目的 探讨神经节苷脂联合大剂量甲基强的松龙冲击治疗对原发性脑干损伤患者预后的影响。②方法 对 2 5例原发性脑干损伤患者采用早期神经节苷脂联合甲基强的松龙冲击治疗 ,分别于伤后 4～ 7天行颅内压监测 ,6个月行GCS、GOS、语言障碍程度及运动功能障碍程度评分 ,并与未进行激素治疗的对照组 2 5例患者进行比较。③结果 与对照组比较 ,采用神经节苷脂联合甲基强的松龙冲击治疗的患者的神经功能恢复速度较快、恢复程度较高。④结论 早期神经节苷脂联合甲基强的松龙冲击治疗原发性脑干损伤 ,对于抑制继发性损伤的发生、发展及改善患者的预后有积极的意义。

Objective To study the therapeutic effect of ganglioside and high-dose methylprednisolone on the prognosis of primary brain stem injury. Methods Ganglioside and high-dose methylprednisolone were used simultaneously from August 2000 to August 2003 on 25 primary brain stem injury patients as early as possible while ICP were monitored respectively in 4～7 days after injury, then 6 months later, Glasgow coma scale (GCS), Glasgow outcome scale (GOS), language barrier degree evaluation and sports function barrier degree evaluation were conducted. The effect were observed and compared with a parallel control test. Results The recovery of those patients who have taken ganglioside and high-dose methylprednisolone were much faster than those who have not, and the degree of recovery was much greater. Conclusion Ganglioside and high-dose methylprednisolone can inhibit the brain injury and definitely improving the patients’ prognosis on early primary brain stem injury.