“莨菪化”治疗对开胸术后肺部并发症的预防

Hyoscyaminization in treatment of postoperative complications after the thoracic surgery

目的 研究开胸术后山莨菪碱“莨菪化”治疗对术后肺部并发症的影响。方法 3 83例普胸手术患者分“莨菪化”治疗组 10 7例 ,非“莨菪化”治疗组 2 76例 ,2组差异仅在于有无“莨菪化”治疗。 2组间年龄、性别、术式、术前心肺功能无显著差异 (P >0 0 5 )。“莨菪化”治疗组采用山莨菪碱 0 81 0mg/kg静脉推注 ,每 6小时 1次至“莨菪化”指征出现。 结果 “莨菪化”治疗组术后 3d内肺功能恢复明显优于非“莨菪化”治疗组〔P <0 .0 1〕 ,术后肺部并发症总数、肺部感染发生率明显少于非“莨菪化”治疗组〔P <0 .0 1〕。结论 开胸术后应用“莨菪化”治疗对术后并发症的预防有明显效果。

Objective To study hyoscyamine in preventing and treating postoperative pulmonary complications after the thoracic surgery.Methods 383 patients with thoracic surgery were divided into two groups.Compared with the control group(n=278),the treated group(n=107)was us ed anisodamine hydrobromide within 3 days by intravenous injection at a dosage o f 0.8~1.0mg/kg every 6 hours till all the indexed appeared.The other aspects o f two groups such as operative type,age,sex,or preoperative cardiac-pulmonary fu nction has no significant difference (P>0.05).Results The treated group showed more effective amelioration than the control group in pulmonary funtion,decreasing postoperative pulmonary complications and pulmonary infection.Conclusion Treatment by hyoscyaminization may be contributed to prevention of postoperative pulmonary complications of thoracic surgery.